Partners in ECHoS work package 3 exchanged experiences and best practices across European countries in a virtual work-shop.

Six-month milestone

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A Norwegian perspective: The foundations of the ECHoS project are laid and Cancer Mission activities are speeding up in Norway.

Over the initial six months of ECHoS, Oslo Cancer Cluster and its collaborators have made significant contributions towards achieving the project’s goals by increasing awareness and mobilising the Norwegian ecosystem for the EU’s Mission on Cancer.

With its early setup of the National Cancer Mission Hub in 2021, Norway is well-positioned to implement the Cancer Mission. Partners of the national hub are taking part in the European effort to establish similar structures in all member states and associated countries, under the ECHoS project.

“ECHoS provides an opportunity to explore new collaborative formats among stakeholders, including patients and citizens. It paves the way to establish novel partnerships across sectors and create opportunities to foster innovation in cancer care.” Marine Jeanmougin, Lead EU affairs and digital innovation in Oslo Cancer Cluster

 

Political discussions

Two public meetings were organised with politicians, experts, and representatives from different sectors in April and August. The debate revolved around the importance to commit to the Mission, how to use Missions as a tool for political change and how Norway can deliver on the Mission.

At the meeting Fremtidens kreftbehandling in April, key opinion leaders discussed how Norway should commit to the EU’s Mission on Cancer. Photo: Sofia Linden

Raising awareness

During The Economist’s World Cancer Series in Brussels, Ketil Widerberg, general manager of Oslo Cancer Cluster, moderated a panel discussion on cancer prevention. Clinicians, policymakers, and patient advocates discussed: How can equal access to screening be guaranteed? And what strategies can be implemented to adopt innovative methods for cancer detection?

Panel discussion with key opinion leaders at The Economist’s World Cancer Series in Brussel. Photo: Dave Tippett

Engaging stakeholders

Oslo Cancer Cluster recently conducted a working session on multistakeholder cooperation. Discussions addressed the possible challenges in establishing complex partnerships but also the opportunities offered by the mission approach to bring concrete solutions to cancer patients. The event fostered bottom-up thinking among ECHoS partners and tapped into the experience that participants have accumulated within their own ecosystems.

A cross-border, multi-national, virtual workshop with partners from ECHoS work package 3, work task 3, delved into new forms of collaboration towards the Mission on Cancer.

About ECHoS

ECHoS is a European project, funded by Horizon Europe Programme. It aims at supporting the implementation of the Cancer Mission activities in all Member State and Associated Country (MS/AC) through the establishment and development of National Cancer Mission Hubs (NCMHs) operating at national, regional, and local levels.

Read more on the ECHoS website.

The post Six-month milestone first appeared on Oslo Cancer Cluster.

The panel discussion about implementing PRS tests included (from left to right): Peeter Padrik, CEO and founder of Antegenes, Solveig Hofvind, Head of the Mammography Programme at the Cancer Registry of Norway, Ole Alexander Opdalshei, Deputy Secretary General at the Norwegian Cancer Society, Lovise Olaug Mæhle, senior consultant at the Department of Medical Genetics at Oslo University Hospital and Ketil Widerberg, general manager at Oslo Cancer Cluster, as moderator. Photo: Wenche Gerhardsen / Oslo Cancer Cluster

Personalising breast cancer screening in Norway

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5 people sitting on stools in fromt of a white screen, being part of apanel for discussion.Wenche Gerhardsen

Are polygenic risk scores the key to personalising cancer prevention in Norway?

Imagine that your saliva can reveal your personal risk for developing certain diseases. Think about the possibilities of detecting cancer at an early stage, preventing serious disease and saving lives. This is what polygenic risk score (PRS) tests are all about.

The AnteNOR project has investigated how such a test for breast cancer can be implemented in the Norwegian healthcare system. In a recent seminar at Oslo Cancer Cluster Innovation Park, researchers and experts met to present the results and discuss the way forward.

Watch the seminar here:

 

Analysing Norwegian data

Eivind Hovig, Professor at the Centre for Bioinformatics at the University of Oslo, and group leader at Institute for Cancer Research, Oslo University Hospital, has investigated the performance of breast cancer polygenic risk score in the Norwegian population.

Eivind Hovig, Professor at the Centre for Bioinformatics at the University of Oslo, and group leader at Institute for Cancer Research, Oslo University Hospital. Photo: Sofia Linden / Oslo Cancer Cluster.

Denise O’Mahony, researcher at the Department of Medical Genetics, Institute of Medical Genetics at University of Oslo, supplemented Hovig’s presentation. Her research group has among other things analysed the distribution of polygenic risk scores in Norwegian data compared to Estonian data.

“By the age of 49 we see a total of 182 women that have a higher risk than the median absolute risk at 50, which is the age that women enter screening, therefore indicating the benefit of incorporating the PRS in clinical practice,” commented O’Mahony.

Denise O’Mahony, researcher at the Department of Medical Genetics, Institute of Medical Genetics at University of Oslo. Photo: Wenche Gerhardsen / Oslo Cancer Cluster.

 

Testing in the clinic

A clinical pilot study at Vestre Viken breast centre has evaluated the impact of implementing population-based genetic testing strategy for breast cancer precision prevention. There were 80 study participants aged 40-50 who took the saliva-based PRS test at the breast centre. Some of these women were ultimately recommended earlier screening or more intensive screening.

“Half of them were recommended to participate in standard screening. Almost half of them were recommended to start screening at an earlier age than 50. One was recommended to start annual mammography screening immediately,” said Tone Hovda, senior radiologist at Vestre Viken.

Tone Hovda, senior radiologist at Vestre Viken. Photo: Sofia Linden / Oslo Cancer Cluster.

 

Is this cost-effective?

As with any innovation, the tests come at a price. Kari Kollstad, health economist at Oecona AS, has developed a cost-effectiveness analysis of a polygenic risk-tailored breast cancer screening program in Norway.

“The preliminary results show that risk-stratified screening is more costly than current mammography screening, mainly driven by: costs associated with implementing the test and consultations, as well as screening costs. Risk-stratified screening also resulted in an increase in life years and quality-adjusted life years, and a redistribution of cancer cases compared to current mammography screening,” said Kollstad.

This means that while the tests come with a cost, risk stratified screening means that breast cancer can be detected at an earlier stage and that patients live longer.

Kari Kollstad, health economist at Oecona AS. Photo: Sofia Linden / Oslo Cancer Cluster

 

Towards individual-based screening

The presentation was followed by a panel discussion about how to implement PRS tests in clinical practice.

“As an oncologist with 33 years of experience, I have encountered numerous cases of advanced breast cancer in women of various ages. When analyzing their risks and individual stories, I realized that we could prevent most of these unfortunate situations. Breast cancer risks vary significantly among women, but our screening approaches are the same for all. It is crucial that we enhance the current real-world practices for breast cancer prevention and screening, especially considering the availability of innovative solutions,” commented Dr. Peeter Padrik, CEO and Founder of Antegenes.

The company Antegenes has developed novel polygenic risk score-based genetic tests to estimate the risk of common cancers.

Peeter Padrik, CEO and founder of Antegenes. Photo: Sofia Linden / Oslo Cancer Cluster

“I believe precision cancer prevention will be the right way for the future. We need to see what we can do to find more women with breast cancer that need to be treated,” commented Ole Alexander Opdalshei, deputy secretary general, the Norwegian Cancer Society.

“We have been doing mammography screening for 30 years now and using the same procedures and equipment, so it is definitely time for change. We need to go more personalised. We need more efficient tools and we need to consider if it is time to extend the age range targeted in the program. I think the Antegenes test could contribute to making BreastScreen Norway more personalized and better for women: if we could start inviting women 48 years old, test all women and plan a personalised screening for the women. It would be expensive, but perhaps cost-effective in the long run,” commented Solveig Hofvind, Head of the Mammography Programme at The Cancer Registry of Norway.

 

Project partners: Antegenes, Oslo Cancer Cluster, Oslo University Hospital, University of Oslo, Vestre Viken.

This project is supported by the Norway Green ICT Programme.

 

The post Personalising breast cancer screening in Norway first appeared on Oslo Cancer Cluster.

Thomas London recently joined the board of Oslo Cancer Cluster Incubator. Photo: private

New incubator board member

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Thomas London

Thomas London has joined the board of Oslo Cancer Cluster Incubator

“It was an honour to be elected to the board,” Thomas London said.

London is a businessman who has been trying to buy property from Oslo municipality to expand Oslo Cancer Cluster Innovation Park to make room for more businesses and laboratories within the cancer sphere. The slow process now seems to have found a solution with the new Oslo City Council.

Read about the assurances from the City Council in the newspaper Dagsavisen (in Norwegian).

This is the entire incubator board. 

An active board member

London underlines the value for society in having an incubator dedicated to new companies working with cancer, often developing innovative Norwegian cancer research.

“The work of the incubator affects many lives and will continue doing so in the future. I wish to be an active board member and support the work of the incubator team in developing the incubator to be even bigger and help even more start-up companies through their first critical years.”

There is also a personal reason why Thomas London was eager to take on a board position in the incubator. Like so many, he has had close relations get cancer.

“I am personally invested in the fight against cancer and in developing better cancer care.”

Expanding the innovation park

As the manager of the real estate development company Oslo Science Hub AS, he oversees the final expansion of Oslo Cancer Cluster Innovation Park. The final expansion is planned to be about 40,000 square metres. London is sure that cancer innovation in Norway will grow with the park.

“In the coming years it will be easier to see the entire Campus Radiumhospitalet as one innovative area,” London said.

Arcitect model of buildings

A model of the planned expansion of Oslo Cancer Cluster Innovation Park. Phase 4 is being built today, between the hospital and the current park. Phase 5, to the far right in the picture, is planned to be built by 2028. The two planned building phases will add about 50,000 square metres to the park. Photo: Fartein Rudjord

You can read more about the expansion plans, and see the building site live, at the Oslo Cancer Cluster Innovation Park website. 

 

The post New incubator board member first appeared on Oslo Cancer Cluster.

Three of the speakers during the CellFIT workshop in Trondheim last week (from left to right): Anna Pasetto, PhD, Director of the Center for Advanced Cell Therapy (ACT), Section for Cell Therapy, Division for Cancer Treatment, Cancer Clinic, Oslo University Hospital, Hanne Haslene-Hox, PhD, Senior Research Scientist, SINTEF, and Else Marit Inderberg, PhD, Senior Scientist, Group Leader, Head of Immunomonitoring, Department of Oncology, Cellular Therapy, Oslo University Hospital. Photo: Dave Tippett.

CellFIT workshop in Trondheim

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How can manufacturing of T cell therapies be improved?

This was a key question at a workshop organised by the CellFIT project in Trondheim last week. The seminar brought together project partners and experts as they tried to address one of the biggest challenges for cell-based cancer therapy – efficient and scalable production.

“One of the key reasons why patients relapse after CAR T-cell therapy is that the therapeutic T cells do not persist in the patients after infusion. We know that patients that have cancer-reactive stem-cell like memory T cells respond better to treatment and these cells persist for a very long time, but these cells are rare. In the CellFit project we will optimize T cell manufacturing to produce more of these T cells for therapy.  OUS has a central role in CAR-T cell development and manufacturing, and can test this in patient T cells,” commented Else Marit Inderberg, PhD, Senior Scientist, Group Leader, Head of Immunomonitoring, Department of Oncology, Cellular Therapy, Oslo University Hospital.

ThermoFisher is one of the project partners and contributes with innovative reagents to ensure optimal growth factors for the cells.

“The Thermo Fisher Scientific team greatly appreciated the workshop and opportunity to meet face-to-face with the team and workshop participants. The presentations were of high quality covering important parts of cell therapy development from the development of novel CAR-T receptors, high-complex assays and initiatives to bring new cell therapies to patients via the ACT center. Already looking forward to the next workshop!” commented Tuva Holt Hereng, Senior Manager R&D Cell Therapy at Thermo Fisher Scientific.

State-of-the-art facilities

The day before the workshop, project partners were given a tour of the SINTEF Labs in Trondheim.

“It was great to welcome both the CellFit team and the workshop participants in Trondheim! Being close to the SINTEF labs a facility tour was a nice way to show some of the infrastructure used for high-throughput process development for the CellFit project. We also got great speakers that showed us the forefront of T-cell therapy development, which was both inspiring and very impressive,” commented Hanne Haslene-Hox, PhD, Senior Research Scientist, SINTEF.

Hanne Haslene-Hox, PhD, Senior Research Scientist, SINTEF gave a tour of the SINTEF labs in Trondheim. Photo: Dave Tippett

Public-private collaboration

To improve therapeutic efficacy, increased collaboration between manufacturers (industries) and patient treatment centers (hospitals) is needed.

“Supporting the scientists and stakeholders in the CellFit Project will help to assure that we reach collective goals. Oslo Cancer Cluster supports this project by providing advisory and opportunities for dissemination of knowledge to the wider oncology ecosystem,” commented Charlotte Wu Homme, Head of Membership and Events, Oslo Cancer Cluster.

Else Marit Inderberg, PhD, Senior Scientist, Group Leader, Head of Immunomonitoring, Department of Oncology, Cellular Therapy, Oslo University Hospital and Charlotte Wu Homme, Head of Membership and Events, Oslo Cancer Cluster. Photo: Dave Tippett

About CellFIT

The primary aim for the CellFit project is to define optimal growth conditions for improved manufacturing of therapeutically active T cells. Established in 2021 and funded by The Research Council of Norway, the CellFit Project is a collaboration led by Oslo University Hospital, Department of Cellular Therapy. The project includes project partners Oslo Cancer Cluster, SINTEF, and Thermo Fisher Scientific.

For more information, please visit the CellFIT website.

The post CellFIT workshop in Trondheim first appeared on Oslo Cancer Cluster.

Professor Åslaug Helland, MD Ph.D. is the Principal Investigator of the NIPU clinical trial, which has demonstrated that malignant mesothelioma patients live longer when treated with the universal cancer vaccine UV1. Photo: Per Marius Didriksen, Oslo University Hospital

First demonstration of universal cancer vaccine

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New data shows 27% improved survival for malignant mesothelioma patients in the NIPU trial.

Positive results from the NIPU trial announced last night show the combination of a universal cancer vaccine and checkpoint inhibitors in patients with malignant mesothelioma reduces the risk of death by 27%.

“For patients with malignant mesothelioma, few treatment options are available after first-line chemotherapy. The NIPU study showed that patients receiving UV1 vaccination as add-on to nivolumab and ipilimumab experienced an increased objective response rate and a clinically meaningful prolonged survival. These encouraging results provide a foundation for advancing further clinical development with UV1 vaccination in mesothelioma patients,” said Principal Investigator of the NIPU clinical trial, Professor Åslaug Helland, MD Ph.D.

Åslaug Helland, Principal Investigator of the NIPU clinical trial. Photo: Per Marius Didriksen, Oslo University Hospital

The ‘gold standard’

This is the first demonstration of the efficacy and therapeutic impact of a universal cancer vaccine in a Phase II trial. The universal cancer vaccine is the lead product of the Norwegian biotech company Ultimovacs, which is developing novel immunotherapies against cancer. The vaccine is currently being tested in five Phase II trials on different cancer indications.

“We are thrilled to announce the highly advantageous results from the first randomized UV1 Phase II trial, marking a major milestone for Ultimovacs. Overall survival is the ‘gold standard’ in cancer treatment. We believe these data support further development in mesothelioma, and we are looking forward to discussing the results with the regulatory authorities,” said Carlos de Sousa, CEO of Ultimovacs.

Carlos de Sousa, CEO of Ultimovacs. Photo: Ultimovacs

Since malignant mesothelioma is a hard-to-treat cancer, the positive results from the NIPU trial give cause for optimism in the ongoing Ultimovacs’ trials for other cancer indications too, including malignant melanoma, head and neck cancer, ovarian cancer, and non-small cell lung cancer.

In October 2023, the FDA ranted Orphan Drug Designation for UV1 in the treatment of mesothelioma, but there is still a way to go before the drug reaches the market. The treatment has to be assessed in a Phase III trial and undergo regulatory approval before becoming widely available.

Improved survival and response rate

Oslo University Hospital leads the NIPU study with support from Ultimovacs and Bristol-Myers Squibb. It includes 118 patients from Norway, Sweden, Denmark, Spain and Australia. The patients are in second-line treatment, which means they already received chemotherapy without beneficial results and have no other treatment options.

The patients were divided into two randomized groups: 59 patients received the universal cancer vaccine in combination with checkpoint inhibitors, and the other group received only checkpoint inhibitors. Results show that patients who received the universal cancer vaccine had a prolonged survival rate and a significantly better objective response rate. This means the patients lived longer and more patients’ tumours shrunk than in the control arm. In addition, the treatment showed no added side effects.

“We want to extend our gratitude to the patients and their families, as well as the dedicated investigators and all our supporters whose invaluable contributions made this study possible,” Helland commented.

For more information, please read the press release from Ultimovacs or follow the company’s webcast on Mon, Oct 23 2023 at 14:30 (CET).

The post First demonstration of universal cancer vaccine first appeared on Oslo Cancer Cluster.

Ketil Widerberg, daglig leder i Oslo Cancer Cluster, er alt i alt ganske positiv til statsbudsjettet 2024.

Statsbudsjettet 2024

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Her er de viktigste sakene i statsbudsjettet 2024 for Oslo Cancer Clusters medlemmer.

Vi har sett nærmere på statsbudsjettet for neste år, og funnet disse lyspunktene for våre medlemmer.

Ekstra til tidligfase

En gründerpakke på 220 millioner kroner ligger ligger bakt inn i statsbudsjettet. 70 millioner av disse kronene skal gå til å styrke Innovasjon Norges ordninger for etablerere og vekstselskap. I tillegg foreslår regjeringen å sette av 150 millioner kroner til investeringer i tidligfasebedrifter gjennom Investinor. Dette er gode nyheter, mener Ketil Widerberg, daglig leder i Oslo Cancer Cluster.

– Offentlig støtte og såkornmidler er et viktig element i å utvikle ny norsk helsenæring, og satsingen er velkommen!

En liten justering og påminnelse er likevel på sin plass.

– Samtidig, med tanke på nye bioteknologiselskap innen kreft, trengs en kraftigere innsats om vi skal lykkes med å tiltrekke og utvikle ideene. Lange utviklingsløp krever betydelig risikoavlastende kapital i tidlig fase. For eksempel hentet nylig radiofarmasiselskapet ArtBio inn 250 millioner kroner bare på en første investeringsrunde, sier Ketil Widerberg.

Les mer om ArtBios første investeringsrunde i MedWatch.

Persontilpasset medisin

Et tilskudd på 110,9 millioner kroner foreslås videreført fra 2023 til persontilpasset medisin. Tilskuddet finansierer blant annet etablering og drift av nasjonalt genomsenter, infrastruktur for presisjonsdiagnostikk (InPred) og det nasjonale kompetansenettverket innenfor persontilpasset medisin (NorPreM). Ketil Widerberg mener at det er gledelig at persontilpasset medisin blir prioritert videre til neste år.

– Persontilpasset medisin er viktig for pasienter, som slipper mange bivirkning og får effektive medisiner. Det er også et område der vi i Norge er i forskningsfronten, har et innovativt samarbeid i det offentlig-private konsortiet CONNECT, og har lovende oppstartsfirmaer som Zelluna Immunotherapy og andre i vårt økosystem.

Les mer om CONNECT på konsortiets hjemmeside.

I en helhetlig satsing på persontilpasset medisin, er diagnostikk og spesielt gentester vesentlige ingredienser.

– Gentester burde satses på i større grad. 

Kartlegger helsekatapult

Tilskuddene til testfasiliteter for oppstartsbedrifter skal økes som et ledd i regjeringens politikk for en grønn omstilling av norsk næringsliv. Konkret vil det si 26 millioner kroner mer til testfasiliteter gjennom Sivas katapultordning i 2024.

Per i dag finnes fem sentre under katapultordningen. De dekker produksjonsteknologi, materialteknologi, digitalisering, hav og marin teknologi og fornybar energi. Det finnes ikke noe eget katapultsenter for helse, men helse var blant fire prioriterte områder i forprosjekter som ble gjennomført i 2019/2020 for ny utlysning av ordningen. I regjeringens veikart for helsenæringen, som ble lansert i august, ba regjeringen Siva, i samarbeid med Forskningsrådet og Innovasjon Norge, om å utrede hvordan helsenæringen i større grad kan få nytte av katapultordningen. Nå øremerkes to millioner statsbudsjettkroner til en slik kartlegging, som del av de nevnte 26 millionene til testfasiliteter. Ketil Widerberg er glad for det.

– Vi er glade for at helsekatapult blir prioritert, og ser frem til å jobbe med de andre helseklyngene for å realisere potensialet for at norsk forskning skal kunne bli til helsenæring og fremtidige industrieventyr.

Totalt får ordningene Norsk katapult og Grønn plattform 214,3 millioner kroner i 2024.

Regjeringens pressemelding kan leses her.

Helsenæring som eksport

Regjeringen foreslår å sette 94,7 millioner kroner inn på å fremme norsk eksport i 2024. Det er en økning på 45 millioner kroner, som et ledd i eksportreformen Hele Norge eksporterer, der helsenæring er ett av årets to nye satsingsområder, som blir lansert av regjeringen i løpet av høsten.

Budsjettpengene går først og fremst til Innovasjon Norges internasjonale satsinger, stiftelsen Norwegian Energy Partners (Norwep), arbeid med eksportprogrammet og profilering. De ulike eksportsatsingene presenteres som prosjekter i denne posten, og har ikke fått øremerkede midler.

Nasjonal kreftstrategi

Til neste år vil regjeringen presentere en oppdatert kreftstrategi, som også skal tre i kraft til neste år. Det følger ingen budsjettmidler med.

I den nye strategien skal ny kunnskap på kreftområdet ivaretas, samtidig som de fem overordnede målene videreføres fra nåværende strategi:

  • Norge skal bli et foregangsland for kreftforebygging
  • Norge skal bli et foregangsland for gode pasientforløp
  • En mer brukerorientert kreftomsorg
  • Flere skal overleve og leve lenger med kreft
  • Best mulig livskvalitet for kreftpasienter og pårørende

– Vi mener det er viktig å se på hvordan vi samarbeider for å nå målene, sier Ketil Widerberg.

Han understreker at ulike samarbeid må være en del av selve strategien.

– Vi har flere etablerte samarbeidsarenaer som vi må videreutvikle, som den norske mission huben, CONNECT-samarbeidet på presisjonsmedisin, og helseklyngesamarbeidet. Det er også rom for bedre samarbeid mellom norske og internasjonale institusjoner, mellom offentlige og private aktører, og på tvers av nasjonale siloer. Hvordan vi samarbeider må være en integrert del av en kreftstrategi – og en mulighet til å få til mer uten flere budsjettkroner, sier Ketil Widerberg.

Les mer om den norske mission huben på cancermission.no.

Ny helseteknologiordning

Helse- og omsorgstjenestene skal bli enklere og mer brukervennlige. Derfor foreslår regjeringen 150 millioner kroner til en ny helseteknologiordning, og 100 millioner kroner til utvikling av digital samhandling i helse- og omsorgssektoren. En helseteknologiordning skal gi kommunene drahjelp for å investere i og ta i bruk helseteknologi. Kommunene kan søke om tilskudd for å skaffe digitale løsninger og finne leverandører.

– For kreftpasienter betyr det mye hva slags teknologi som er tilgjengelig der de bor, for å få en effektiv oppfølging etter kreftsykdom. Vi ser derfor frem til at en satsing på helseteknologiordning vil kunne bidra til bedre oppfølging av pasientene.

Til grunn ligger en ramme på 1,25 milliarder kroner over seks år for å gjennomføre de nasjonale tiltakene for digital samhandling. Her gjelder det å bruke pengene smart, og etablere det vi mangler innen helseteknologi.

– For å gjøre bruk av ny teknologi i helse, mangler vi etablerte prosesser, budsjetter og samarbeid om helseteknologi, slik som vi har på legemidler. Spesielt blir dette tydelig for digitale løsninger, sier Ketil Widerberg.

Andre kreftrelaterte bevilgninger

  • Tarmkreftscreeningprogrammet fortsetter med videreførte 215,1 millioner kroner.
  • Hjemmetest i livmorhalsprogrammet får 26 millioner kroner i 2024.
  • Hudkreftstrategien og UV-nettverket får 2 millioner kroner ekstra, som blant annet skal gå til oppmerksomhetskampanjer.

 

Vite mer om statsbudsjettet 2024? Du finner alle budsjettdokumentene på regjeringen.no.

 

The post Statsbudsjettet 2024 first appeared on Oslo Cancer Cluster.

Photo: SurViva

SurViva joins Oslo Cancer Cluster

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Surviva

Meet the newest member of Oslo Cancer Cluster – SurViva, a Norwegian consultancy providing quality guidance for life science companies.

“Cancer research is one of SurViva’s strategic areas of focus, as this is an area where Norway clearly has the potential to develop innovative treatments and value-creating businesses. SurViva is joining Oslo Cancer Cluster to offer our comprehensive Quality package enabling businesses to more efficiently turn great science into lifesaving products,” said Astrid Hilde Myrset, CEO of SurViva.

SurViva is a small Norwegian consultancy offering services including quality assurance (QA) and customised digital quality management systems (eQMS) to health start-ups.

“Quality assurance and the establishment of a quality management system may represent a significant hurdle for small developing companies. Historically, the solution for the individual company has been to employ a QA in a 100% position. A newly hired QA is often alone, may have limited experience, and can easily end up creating resource-intensive systems that can grow out of proportion and require an unnecessary amount of time and expense for the company,” said Myrset.

Focus on quality

SurViva works to grow a pool of quality expertise available for several companies in parallel, to accelerate product development and promote industrial growth.

“In this way, the individual company can get started with its quality system at the right time and have flexible access to qualified resources at any time throughout the development process. When desirable, own QA personnel may be hired, and by having access to a competence pool, it will be easier to make smart choices based on shared experiences and expertise,” said Myrset.

Helping developing companies

SurViva became a member of Oslo Cancer Cluster in September 2023 to contribute to the organisation’s vision of accelerating cancer treatments and diagnostics that improve patients’ lives.

“We think our vision is very well aligned with Oslo Cancer Cluster’s vision. Our Quality package will save time and costs for developing companies, and thus enable accelerated development of new cancer treatments,” said Myrset.

 

The post SurViva joins Oslo Cancer Cluster first appeared on Oslo Cancer Cluster.

Eivind Hovig, Professor at the Department of Bioinformatics at the University of Oslo, is one of the co-authors behind the research article published in MDPI Cancer.

New research on genetic risk and breast cancer

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How a simple saliva test can reveal the risk of breast cancer in the Norwegian population.

A study by the University of Oslo, Oslo University Hospital and OÜ Antegenes looking into Polygenic Risk Scores (PRS) and breast cancer in Norway was recently published in the journal MDPI Cancer. PRS technology is a type of genetic test that can reveal an individual’s risk of developing cancer.

“The study was initiated to assess the possibility of using a combination of genetic markers for a given woman here in Norway to predict the risk of developing breast cancer over her life,” said Eivind Hovig, Professor at the Department of Bioinformatics at the University of Oslo, and one of the co-authors to the article.

Early detection

Every year, there are close to 4 200 new breast cancer cases and almost 600 deaths from breast cancer in Norway, according to reports from the Norwegian Cancer Registry. Early detection is crucial for survival, but almost 40 per cent of breast cancer cases are not diagnosed at an early stage.

“The results indeed indicate that it is entirely feasible to apply such a predictor meaningfully in a Norwegian context,” said Hovig.

Personalised screening

Current breast cancer screening in Norway is implemented for women at age 50-69, but approximately 20 per cent of breast cancer cases are diagnosed in younger women. These tests can potentially be used to identify younger women with a higher risk and lead to a more personalised screening approach.

“As the application of such a predictor may have implications for management of patients with high risk scores, it may lead to different screening strategies and a better understanding of the risk profiles of these patients,” added Hovig.

The PRS test used in the study was developed by the Estonian company Antegenes. The study was conducted as a part of AnteNOR, a project that investigates how PRS can be implemented for prevention and early detection of breast cancer in Norway.

The post New research on genetic risk and breast cancer first appeared on Oslo Cancer Cluster.

Ministers Jan Christian Vestre and Ingvild Kjerkol released the roadmap for the health industry from Nykode Therapeutics laboratories. Photo: Nærings- og fiskeridepartementet

A roadmap for the health industry

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How will Norway commercialise research and turn health into a green export success?

The roadmap for the health industry was released today by Ingvild Kjerkol, Minister of Health and Care Services, and Jan Christian Vestre, Minister of Industry, Trade and Fisheries. The roadmap includes 12 focus areas and 41 actions, which the two ministries have worked together with industry to identify.

Commercialising research

One of the focus areas is testing and piloting of novel health solutions.

“We will become better at commercialising research results and create industry. We want the state to contribute considerably more so companies have access to testing facilities, so they can develop their solutions. We will develop the catapult scheme for the health industry,” said Vestre.

Today there is no health catapult in Norway. SIVA, the Research Council of Norway and Innovation Norway will now investigate how the health industry can better utilise the catapult scheme.

“The health clusters are ready to contribute! Based on work we did in 2019 and 2020, Oslo Cancer Cluster, Norwegian Smart Care Cluster and Norway Health Tech have set up Health Catalyst, a national arena for developing, testing and piloting novel solutions in health. Among other things, we have signed an agreement to collaborate with Nortrials,” commented Ketil Widerberg, general manager of Oslo Cancer Cluster.

A green export opportunity

In 2021, the Norwegian health industry had a total turnover of NOK 65 billion, where NOK 22 billion came from export alone, according to a Menon Economics report (2023).

“The health industry has a natural place in a low emission society. We believe we can increase the export from the health industry considerably, and this will contribute to solve global challenges and create workplaces in our own country,” commented Vestre and added there will be additional funding for this.

The Norwegian health industry is united through the clusters and is ready to contribute as the government launches this historical investment.

“When we work with pharma and biotech, we create green workplaces. We work to establish national production, local testing, and precision medicine, which will shorten value chains, as well as decrease transport and logistics,” commented Widerberg.

A supercluster is needed

The Norwegian clusters were also mentioned especially for their ability to facilitate collaboration and knowledge transfer between large and small companies, and research environments – which will strengthen the success of Norwegian export.

“We want to clarify that the three internationally renowned, National Centres of Expertise (NCE) clusters in health, including Oslo Cancer Cluster, Norwegian Smart Care Cluster and Norway Health Tech, wish to unite into a supercluster.

“We hope the revised cluster programme builds on an understanding that all parties must contribute to the development and financing of the clusters to make public-private collaboration a reality,” commented Widerberg.

Towards a Cancer Mission?

Kjerkol also mentioned several actions that will make a big difference for the development of cancer therapeutics and diagnostics in Norway. These include:

  • Securing that research milieus in the private and public sector get guidance on clinical studies
  • Developing the Directorate for Medical Products
  • Facilitating access to health data for the health industry
  • Investing in clinical studies and personalised medicine
  • Creating a strategic arena for dialogue between health authorities and industry

“Oslo Cancer Cluster is delighted that input we have made over the last two years towards public policy are taken seriously in this roadmap, but there is still work to do. Our project CONNECT shows the opportunities of public-private collaboration in implementation of precision medicine including regulatory innovation. We applaud that the government wants to build on this.”

“We believe these combined efforts represent the first steps towards Norway making its mark internationally and are a contribution to the European Mission on Cancer,” said Widerberg.

Oslo Cancer Cluster has set up a hub to pursue the EU’s Cancer Mission nationally, together with the Research Council of Norway, the Cancer Society and several other key players.

 

 

The post A roadmap for the health industry first appeared on Oslo Cancer Cluster.

A panel conversation about how personalised medicine can create value in the national health service. From left to right: Åsmund Flobakk, oncologist at St Olavs hospital, Siri Børø, Medical Advisor Oncology at Merck, Giske Ursin, director at the Cancer Registry of Norway and Ulrich Spreng, Chief Medical Officer of Helse Sør-Øst.

Personalised medicine to relieve the health service

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Smaller patient groups and targeted treatments are the future of cancer care in Norway.

It is no longer a question of if but when personalised medicine will be a reality for all cancer patients in Norway. This was a key message in a recent meeting arranged by the public-private consortium CONNECT during Arendalsuka, where the resource crisis in the health service was discussed.

Forward-looking health authorities

Ulrich Spreng, Chief Medical Officer of the South-Eastern Regional Health Authority (Helse Sør-Øst), underlined how critical personalised treatments will be in the future. Spreng sits in the Decision Forum of New Methods, the national system that manages the introduction of new treatments in Norway. The Decision Forum looks at three criteria; the severity of the disease, the effect of the treatment and the resources it requires.

“If you can target treatment better according to an individual patient’s genetic profile, there will be a greater effect. This makes it easier to implement that drug since it is a different relationship between resources and effect than when you treat a large patient group where many do not have an effect. It is important for us to separate a total patient group into subgroups according to their genetic profile. This is very exciting for New Methods!” Spreng commented.

Urgent lack of resources

The Norwegian health service faces a lack of resources and personnel, according to an investigation by the Health Personnel Commission in 2022. Gro Live Fagereng, Coordinator Precision Cancer Medicine at Oslo University Hospital, agreed this is a major challenge:

“We have limited time and finances in the health service, so we must prioritise the available resources. Both personalised medicine and research in general form the basis for making the best priorities. We need to invest in research to make the most of our resources. I hope and believe we will have a more systematic and learning health service in the future; that we will learn more from patients, so we can update treatments and make better priorities.”

Åsmund Flobak, oncologist at St. Olavs Hospital, explained how personalised medicine enables us to learn from patients:

“Traditionally, we have treated patients on a group level, but we know that patients are different; some respond and some do not. The goal is to find out which biomarkers relate to which treatments. We have worked to establish publicly financed precision diagnostics through InPreD and we give patients precision treatment through IMPRESS. A third of us will at some point get cancer, so we must implement better treatments.”

Watch this video (in Norwegian) to understand personalised medicine:

Health economists also agree that this strategy can help to save resources.

“When a patient gets the right treatment, you avoid giving a treatment that doesn’t work well enough first and there are fewer side effects. The consequence is less use of resources in the health service and we can live better lives,” commented Erik Magnus Sæther, Partner at Oslo Economics.

Public-private collaboration needed

Karoline Knutsen, Manager Market Access at Legemiddelindustrien (LMI), said that the vision for the future looks grim:

“The number of people of working age will decrease, while there will be more elderly in need of health services. We will see more chronically ill people with complex diseases. We believe new technologies and treatments are part of the solution, so more of us can keep working. The success of implementation of personalised medicine relies not just on financial investments, but also on contributions from many key players and stakeholders. Everyone must sit around the same table.”

CONNECT was set up to be that table, as a public-private consortium driving the implementation of precision cancer medicine in Norway. Since 2020, CONNECT has gathered 30 partners, including industry, patient organisations, university hospitals and several governmental institutions.

“We need to nurture this collaboration, develop it and use it in more areas,” commented Thomas Axelsen, Head of Politics at the Norwegian Cancer Society. “Personalised medicine in cancer needs to happen, no matter what. It is just about how fast we want it to happen. If we do it faster, we can save patients’ lives.”

Political ambitions

The government’s ambition is also high in this area, as seen in the Strategy for Personalised Medicine launched in January 2022.

“Personalised medicine should be an integrated part of the specialist health service. We need to develop the health service in a way that maximises value creation, both for the individual and for society as a whole,” said Truls Vasvik, State Secretary of the Ministry of Health and Care Services.

“Our doors are always open. We need to talk together about the development of competences, research and new price models; how we can get documentation of small patient groups and single treatments with uncertain long-term effects,” added Vasvik.

The post Personalised medicine to relieve the health service first appeared on Oslo Cancer Cluster.