The expert panel discussed how Norway can implement a Cancer Mission. From left to right: Idar Kreutzer (NHO), Cathrine Lofthus (Ministry of Health and Care Services), Jónas Einarsson (Radforsk / Oslo Cancer Cluster), Astrid Bjerke (Norwegian Cancer Society), Erik Aasheim (moderator, Primus Productions).

Arendalsuka: – We need to attract the big companies

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Norway needs more big companies to deliver on the Mission on Cancer.

The European Union has launched the Mission on Cancer with the goal to improve the lives of 3 million Europeans. In the recent meeting Fremtidens kreftbehandling during Arendalsuka, key experts and politicians gathered to discuss the implications of this for Norway. See the meeting here. See the meeting here. 

“With missions, we need to mobilise all resources in society towards a common goal. This is a new way to work and it challenges the established system. It is a historic investment from the EU; they are leaving no stone unturned in the fight against cancer,” said Astrid Bjerke, strategic adviser for the Norwegian Cancer Society.

A Norwegian Cancer Mission Hub has already been set up in Norway by several stakeholders, including Cancer Society, Oslo Cancer Cluster, The Research Council, The Norwegian Health Directorate, the Cancer Registry of Norway, and more.

“Norway is a part of the Mission on Cancer and this is important both for the ministry and from political leadership. EU has seen that we have to work together in the area of health. It is important that Norway is a part of this, because it also gives us possibilities.

“We have a great health service and fantastic health data, which we need to take better advantage of. We have a high degree of knowledge and fabulous research environments, as well as a population with a high degree of trust. Many positive things are happening, but we need to attract the big companies and their competence,” said Cathrine Lofthus, Secretary General of the Ministry of Health and Care Services.

Successful industry collaborations

Idar Kreutzer, director of The Confederation of Norwegian Enterprise (NHO), gave several historic examples of how Norway has built industries based on public-private collaboration, such as water power and the oil industry.

“We were impressed when we saw the power of the development of vaccines during the pandemic, which was a real collaboration between authorities, researchers and industry – with impressive results! The health industry is already exporting for more than NOK 20 billion per year, but the potential is even larger and Norway has perfect conditions to grow a health industry,” said Kreutzer.

One example of a current collaboration between academia and industry is the Oslo Cancer Cluster Innovation Park, which is expanding and has recently signed a lease agreement with the global company Thermo Fisher Scientific.

“We are doing many of the right things in Norway from basic research to patient treatment, but we need to look at the whole ecosystem. We built this ecosystem in miniature around the Radium Hospital, because this is where most of the cancer patients come through and most cancer research is done. It has been a difficult journey, but we have a very exciting pipeline with several up-and-coming companies and promising treatments,” said Jónas Einarsson, CEO of Radforsk Investment Fund and founder of Oslo Cancer Cluster.

Is there political will?

There seemed to be broad political consensus around the Cancer Mission among the politicians at the meeting.

“Missions and the EU’s work in this area is a part of our new cancer strategy and we have to collaborate on this, as well as collaborate with the EU. The mission concept is nothing new. It is first and foremost about achieving collaboration between the health service and the industry. Our cancer strategy will lay the basis for this: to gather all resources around a common goal,” said Even Røed, the Labour Party (Norway).

“We need to replace the income from oil and gas with new industries, which need to have large potentials. All Nordic countries have managed to make their health industries grow. Now we have the opportunity in Norway. The health service, academic milieus and industry are already gathering momentum, but there is a lack of political will. Norway has joined the Mission on Cancer, but how will it be implemented in Norway? There needs to be political will to build the health industry,” said Alfred Bjørlo, the Liberal Party (Norway).

“This is a really exciting method, to involve civil society, industry and academic milieus. I am most concerned about this being politically anchored. Will we see it when the new Cancer Strategy is presented? Will we see the Minister of Health together with the Minister of Industry and a representative from the European Union? Will we be connected to the Europen Union, or will this be a Norwegian hobby project, where we don’t take advantage of the big advantages we have?” asked Kristoffer Robin Haug, Green Party (Norway).

 

The meeting was organised by Oslo Cancer Cluster, the Norwegian Cancer Society, Legemiddelindustrien LMI, MSD Norway, Janssen Norway and AstraZeneca Norway. Thank you to our collaboration partners!

 

The post Arendalsuka: – We need to attract the big companies first appeared on Oslo Cancer Cluster.

Arendalsuka 2023

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Møt oss i Arendal! Vi skal sette kreftinnovasjon på den politiske dagsorden!

Våre arrangementer streames direkte via vår YouTube-kanal @OsloCancerCluster. 

 

Fremtidens kreftbehandling

Tirsdag 15. august, kl. 08.00-09.00, Clarion Hotel Tyholmen Sal A

Velkommen til frokostseminar om samfunnsoppdraget kreft.

Hvert år får 3,5 millioner europeere diagnosen kreft. Om utviklingen fortsetter, vil tallet være 4,3 millioner i 2035. Kreft er i dag den vanligste dødsårsaken i Norge og i flere europeiske land. Utfordringen på kreftområdet er med andre ord formidabel – og økende. Nettopp derfor har EU definert kreft som en av fem store samfunnsutfordringer, som har fått sine tilsvarende målrettede samfunnsoppdrag, såkalte missions. Disse oppdragene skal føre til løsningsforslag på vår tids største utfordringer innen miljø, klima og kreft.

Hvordan kan vi best lykkes med et samfunnsoppdrag på kreft i Norge? Hva har helsenæring og eksport med et samfunnsoppdrag på kreft å gjøre? Og er det ønskelig fra politisk hold å bruke missions som metode? Dette er sentrale spørsmål vi vil debattere med politikere og samfunnsaktører under dette frokostseminaret i møteserien Fremtidens kreftbehandling.

Arrangører: Oslo Cancer Cluster, Kreftforeningen, Legemiddelindustrien, Janssen Norge, MSD Norge, AstraZeneca Norge

Medisinsk innovasjon etter Inflation Reduction Act

Tirsdag 15. august, kl. 14.30-15.30, Clarion Hotel Tyholmen Sal A

Hvordan vil USAs enorme støttepakke til egen industri påvirke medisinsk innovasjon i Europa og Norge?  

Amerikanerne har lansert en støttepakke til egen industri, kalt Inflation Reduction Act. Denne vil påvirke investeringer i forskning og innovasjon i USA, og få ringvirkninger for Europa og Norge.

Inflation Reduction Act, som ble vedtatt i amerikansk lov i fjor, skal få fart på det grønne skiftet og redusere inflasjonen i USA. Men kommentatorer peker på at det vel så mye er en gigantisk pakke for å hente industri og arbeidsplasser hjem, blant annet gjennom subsidier. I pakken kommer også en rekke tiltak som påvirker utvikling av legemidler. Blant annet har flere legemiddelselskaper uttrykt bekymring for en betydelig usikkerhet knyttet til investeringer i forskning og utvikling, og at flere fremtidige kliniske studier kan bli satt på pause.

Hvordan skal Europa og Norge svare på dette?

Historisk har Europa vært ledende på medisinsk innovasjon, men de siste tjue årene har vi falt etter USA. I 2002 var forskjellen mellom investeringer i forskning og utvikling i helseteknologi mellom USA og Europa på 2 milliarder euro, og i dag har denne forskjellen blitt 25 milliarder euro. På tross av dette er Europa i en unik situasjon til å ta over lederrollen innen medisinsk innovasjon, med et helsevesen i verdensklasse, og en lang historie innen forskning og utvikling. Når USA nå satser tungt på egen industri, er det en mulighet for Europa til å intensivere sin egen innovasjonskraft innen helse.

Medisinsk innovasjon er avhengig av et levende økosystem mellom private aktører, helsetjenester og akademia. Derfor vil vi invitere aktører fra det norske økosystemet for å diskutere hvordan Europa, inkludert Norge, skal svare på den globale utviklingen som USA nå dytter framover med sin nasjonale støttepakke.

Arrangører: Oslo Cancer Cluster, Abbvie, Photocure

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The Future of Digital Health in Norway: Leading the Way

Onsdag 16. august, kl. 13.30-14.30, Rygerelektra

Digital solutions offer significant potential to enhance healthcare delivery and innovation for Norwegian businesses. Despite a multitude of available apps, global downloads, and opportunities, many healthcare systems struggle with effective utilization due to trust issues and market complexity. This event highlights successful European cases, aiming to inspire Norway to become a pioneer in secure and impactful digital healthcare solutions.

Agenda:

13:30 – Introduction and Moderation Presented by Stephen McAdam from DNV

13:35 – Norges strategi for implementering av digitale helse teknologier Presented by Lucie Aunan, Divisjonsdirektør at Direktoratet for eHelse (Presentation in Norwegian)

13:40 – The Importance of Certification for Norwegian Municipalities Presented by Terje Wistner, Director ehealth at KS

13:45 – Sleepio: Experience from the UK and Other Countries (Video)

13:48 – A European Perspective: What’s Working and What’s Not Presented by Liz Ashall Payne, CEO and Founder of Orcha

14:00 – Challenges of Implementing Digital Solutions in Norway Presented by Solvor Øverlien Magi, CEO of Lifeness

14:07 – Round Table Discussion Participants: KS, Lifeness, Orcha, CEO of Norwegian Smart Care Cluster Arild Kristensen representing Norwegian Health clusters

14:25 – Summarizing Comments Presented by Stephen McAdam

14:30 – Closing Remarks

Arrangører: Oslo Cancer Cluster, Norway Health Tech, Norwegian Smart Care Cluster, The Life Science Cluster, DNV

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Kan persontilpasset medisin bidra til å løse ressurskrisen i helsetjenesten?

Onsdag 16. august, kl. 16.30-17.30, Clarion Hotel Tyholmen Sal A

Konsortiet CONNECT inviterer til diskusjon om persontilpasset medisin i lys av ressurskrisen i helsetjenestene.

Hva er de største ressursutfordringene helsetjenesten står overfor – og hvordan kan persontilpasset medisin bidra til å løse disse?

I løpet av denne timen tar vi på oss fremtidsbrillene. Vi ser på hva den nye strategien for persontilpasset medisin sier om utsiktene for mer presis behandling, og hvordan blant annet data fra norske kreftpasienter kan bidra til en mer effektiv bruk av helsepersonell og ressurser.

Både fagfolk og politikere deler sitt syn på hva som vil skape bedre ressursbruk i helsetjenesten i årene framover, og hvilken plass persontilpasset medisin bør få i helsetjenesten.

Arrangører: CONNECT

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Du finner mer informasjon om alle arrangementer i Arendal via Arendalsuka.no

The post Arendalsuka 2023 first appeared on Oslo Cancer Cluster.

Karsten Rydén-Eilertsen, Head of Proton Therapy Physics at Oslo University Hospital, is testing the new technology from Kongsberg Beam Technology in a clinical environment, and hopes to improve the precision of radiation therapy.

AI for more precise radiation therapy

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Artificial intelligence is changing the way radiation therapy is used to combat cancer.

A Norwegian technology, developed by the company Kongsberg Beam Technology to improve the precision of external beam radiation therapy, is being tested at Oslo University Hospital.

“There are almost half a million Norwegians living with cancer today. Many more cancer patients survive after radiation therapy, but that doesn’t necessarily mean the patients get well. What concerns us most today is to create treatment plans with less side effects,” said Karsten Rydén-Eilertsen, Head of Proton Therapy Physics at Oslo University Hospital and responsible for the test project.

Huge developments

Karsten Rydén-Eilertsen has worked with radiation therapy at Oslo University Hospital for 33 years. He remembers when the doctors had to make radiotherapy plans for cancer patients using only 2D X-ray images and palpating the tumour site with their hands. Medical physicists and radiotherapy technicians would calculate the dose using standardised charts.

“I have experienced an explosive development in the field of radiation therapy against cancer. We now only use three- and four-dimensional images that we transfer to a sophisticated treatment planning system, where we can outline the tumour and vital organs in detail. There are advanced algorithms for calculating the exact right doses for the individual patient,” Rydén-Eilertsen explained.

These developments are thanks to major advancements in imaging technology, computer power, programming and data handling.

“The big difference today is that the level of personalisation and precision is much higher. We can deposit a high dose of radiation that can destroy the tumour while sparing healthy tissue,” Rydén-Eilertsen commented.

Still many side-effects

With radiation therapy, doctors aim to eradicate the tumour, while minimizing the damage to healthy tissue and vital organs.

“It is a difficult balancing act, because sometimes the organs are so close to the tumour that you can’t avoid affecting them with radiation. Sometimes, you need to choose between destroying the tumour and keeping a vital organ,” Rydén-Eilertsen said.

This dilemma isn’t unique for radiation therapy, but is also true for other cancer treatments, such as surgery and chemotherapy.

“With radiation therapy, you will never have zero radiation dose to the surrounding tissue. There will always be some side-effects. My hope with proton therapy is that these side effects will be reduced,” added Rydén-Eilertsen.

Photons vs. protons

Traditional radiation therapy involves beaming millions of photons through the patient’s body to the tumour. The photons deposit radiation all along their way through the body before exiting. It is not possible to control the photons to only deposit radiation to cancer cells.

“Proton therapy is different. Protons are heavy particles that loose most of their energy the moment they stop. By adjusting their initial speed, you can direct them to deposit most of the radiation dose at the site of the tumour. This means that you don’t affect tissue ‘behind’ the tumour and there is minimal damage ‘in front’ of it. This opens for the possibility to greatly reduce side-effects,” explained Rydén-Eilertsen.

The challenge with protons however is that they are very sensitive to which type of tissue they pass through. The energy loss will be different in bone versus in fat.

“In proton therapy, changes in the patient’s body during treatment are critical. The anatomy of the patient may change from when we take the first CT scan for treatment planning to the day of treatment. A treatment course may take several weeks and involve 30-40 treatment sessions. The anatomy may change both between and during a session. Ideally, one may think that a new plan should be created for every session, but today we don’t have the resources for this. That is why we introduce margins to ensure that the tumour gets properly irradiated every time. Sometimes these margins need to be so large that the patient may still get side-effects,” said Rydén-Eilertsen.

First of its kind

This is where the MAMA-K technology developed by Kongsberg Beam Technology comes in. It can build a digital twin of the patient representing their anatomy as accurately as possible. The twin is created by using advanced mathematical models that allow for all image data sets to be combined into a longitudinal, virtual representation of the patient’s anatomy.

“With this mathematical modelling, we can visualize and quantify how the patient’s body, tumour and vital organs change over time, as well as, make an accurate scoring of the accumulated doses to the tumour and organs at risk,” said Rydén-Eilertsen.

This system will generate knowledge about how different cancer patients’ bodies, tumours and vital organs change while undergoing radiation therapy and the impact this may have on the delivered dose. This will be valuable when starting up proton therapy centres in Norway.

“The mathematical models may make it possible to even predict anatomical changes and the related consequences for the dosage. Artificial intelligence can tell us how the patient might look in 24 hours, so we can create a treatment plan accordingly. The next day, we can take a new CT image and compare if the AI’s prediction is correct. We can then introduce smaller margins, which will also reduce side-effects,” explained Rydén-Eilertsen.

There are 16 treatment machines that generate 3-dimensional data and 2 000 patient appointments every week at the Radium Hospital, generating a large volume of potential test data, which could map changes in cancer patients receiving radiation therapy.

“These data will be extremely valuable when we enter the era of proton therapy because they will tell us more about how patients’ bodies change. Then we can become better at adapting treatment plans and hitting the tumour directly,” explained Rydén-Eilertsen.

AI to identify organs

The next step will be to adjust the treatment plan while the patient is on the table by using real-time images. To accomplish this, the shape and location of the tumour and organs at risk must be extracted from the images. The use of AI will be crucial to realize the speed needed. AI models to identify different parts of the anatomy must be trained and tested – something Kongsberg Beam Technology hopes to have in place soon.

“One of the biggest workloads in radiation treatment today is that doctors must manually outline the tumour and organs at risk in the CT images. We have already tested AI methods to identify anatomic parts of the body, especially vital organs, and the models are very good at this. To find tumours is a different story. We have tested some models that can find breast tissue, and they work well. I think it is only a matter of technological development. A lot will happen in this area,” said Rydén-Eilertsen.

Norwegian proton therapy centres

There are two proton therapy centres being built in Norway and Rydén-Eilertsen believes the MAMA-K technology will be very useful in these centres.

“The exciting part about the establishment of proton therapy is that the number of patients eligible for treatment is quite small, perhaps between 100-200 patients every year, while the capacity of the centres is around 800 patients a year. About 70-80 per cent of patients will be recruited via clinical studies, which have the goal to document that side effects are less with protons than with photons. In this setting, it is super important to know what the patient looks like, and MAMA-K will be a useful tool to achieve this. I don’t know about anyone else that is developing this kind of technology. It is truly unique,” said Rydén-Eilertsen.

 

Kongsberg Beam Technology is a member of Oslo Cancer Cluster and participating in the Accelerator Programme at Oslo Cancer Cluster Incubator. Read more about the company at their website https://www.kongsbergbeamtech.com/

 

The post AI for more precise radiation therapy first appeared on Oslo Cancer Cluster.

Pascal van Peborgh, Senior Director Medical Affairs for Gilead Nordics.

Gilead joins Oslo Cancer Cluster

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Gilead

The newest member of Oslo Cancer Cluster is Gilead, a biopharmaceutical company advancing innovative medicines to prevent and treat life-threatening diseases.

Pascal van Peborgh, Senior Director Medical Affairs for Gilead Nordics answered some questions on why Gilead joins Oslo Cancer Cluster, how they are involved in the cancer field and why the Nordics is an important area for the company.

What is Gilead’s motivation to join Oslo Cancer Cluster (OCC)?

“Gilead’s ambition is to build strong partnerships with cancer research centers and oncology-focused organizations to accelerate research and ultimately provide Norwegian patients with novel therapeutic options. We want to work together with other OCC members on basic research topics and in finding ways to provide better access for patients who suffer from cancer. Part of this ambition was why we partnered in the CONNECT public-private partnership.”

Tell us more about Gilead’s investment in cancer and the company’s oncology pipeline.

“Gilead has a long history of bringing innovation to patients in improving patients’ outcomes and at times provided a cure for people facing specific life-threatening infectious diseases such as HIV and Hepatitis C. Gilead is now applying the same approach and commitment to cancer. We have purposefully built a deep and broad oncology portfolio with a focus on trying to address critical unmet needs in oncology care.

“This framework defines our portfolio, with assets that have complementary MOAs and strong scientific rationale for treatment combination opportunities. From antibody-drug conjugates and small molecules to cell therapy-based approaches, our research and development programs are providing new hope for people with overlooked, underserved, and difficult-to-treat cancers.

“This includes many of the most exciting and most promising targets in oncology today, with strong potential across tumor types, lines of treatment, and multiple opportunities for unique combination therapies. We have investigational agents in trials across varied solid tumors: breast, lung, GI, GU, including bladder, among many others. And in blood cancers: MDS, AML, LBCL, adult lymphoblastic leukemia and more. We are well positioned to establish Gilead as a leading Oncology company.”

What do you think about opportunities in Norway, and the Nordics, for the development of new cancer treatments? How do you view the milieus here for cancer research and health industry?

“We see Norway as a pioneer in Precision Medicine, e.g., the CONNECT and IMPRESS initiatives. It has also a strong history of registry data utilization, e.g., and building further new additions to cancer registry like INSPIRE BC and LC. Norway is also highly ranked for cancer research in Europe, with a government and policies supporting the development of precision medicines and clinical trials, with Inven2 and NorTrial being established as examples.

“In addition, the systematization of care in Norway and especially around Oslo University Hospital provides a central node with adequate infrastructure, expertise, and innovation in the cancer research eco-system and more specifically for translational research and clinical trials. Finally, the Oslo University Hospital being an accredited Comprehensive Cancer Center with an extensive international network provides us with further confidence to invest in cancer research in Norway.“

Do you have an ambition to launch cancer clinical trials in the Nordics?

“Our ambition is to continue to initiate new clinical trials within oncology in the Nordics in greater scope, and more specifically in Norway. We at Gilead, view the Nordic countries as having high-quality infrastructure that supports clinical research and studies. The countries have national support functions that provides information and services to researchers that are interested in clinical research – both for observational studies and for clinical interventional studies.

“Gilead, with its own R&D portfolio or through opt-in agreements has currently more than 70 ongoing oncology R&D programs focusing on three therapeutic strategies: triggering tumor intrinsic cell death, promoting immune-mediated tumor killing, and remodeling of the tumor microenvironment. To be able to fully deliver on this pipeline we will need close collaboration with clinical and academic research.”

 

Learn more about the members of Oslo Cancer Cluster by visiting our Member Overview page.

The post Gilead joins Oslo Cancer Cluster first appeared on Oslo Cancer Cluster.

Krista Kruuv-Käo, project manager of AnteNOR, presented how polygenic risk scores can be used to prevent breast cancer at a recent meeting organised by the Norwegian Cancer Mission Hub. Photo: Sofia Linden / Oslo Cancer Cluster

Polygenic risk scores: a European cancer priority 

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The EU is looking to polygenic risk scores to improve prevention and early detection of cancer

Polygenic risk scores (PRS) have become one of the focus areas for prevention and early detection of cancer in the European Union’s Mission on Cancer. 

“PRS tests can provide a measure of your personal risk of developing a specific disease due to your genes,” explained Krista Kruuv-Käo, project manager of AnteNOR, a project that investigates how PRS can be implemented for prevention and early detection of breast cancer in Norway. 

Europe’s Beating Cancer Plan outlines 10 flagship initiatives and number 7 focuses on how cancers develop: 

“Alongside the ‘Genomic for Public Health’ project, the European Initiative to Understand Cancer (UNCAN.eu), planned to be launched under the foreseen Mission on Cancer to increase the understanding of how cancers develop, will also help identify individuals at high risk from common cancers using the polygenic risk scores technique. This should facilitate personalised approaches to cancer prevention and care, allowing for actions to be taken to decrease risk or to detect cancer as early as possible.”

What about Norway?

There are about 4 200 new cases and almost 600 deaths due to breast cancer in Norway each year, according to reports from the Norwegian Cancer Registry.  

“Early detection of breast cancer can save lives, but approximately 40 per cent of breast cancer cases in Norway are not detected at an early stage. For breast cancer, 31 per cent of all diagnoses are due to genetic predisposition and many women develop cancer before they reach the screening age of 50,” Kruuv-Käo commented. 

There are already genetic tests in the Norwegian specialist healthcare service for monogenic pathogenic variants, such as BRCA1 and BRCA2, but not on a population-wide basis. PRS tests have not been implemented yet, although they are both cheaper and can identify more women with a moderate to high risk of developing breast cancer. 

Improving cancer screening

The results of the AnteNOR project were recently presented at a meeting organized by the Norwegian Cancer Mission Hub. 

“The project shows that PRS tests can be used for effective risk stratification for population-wide breast screening. By introducing genetic risk testing with PRS tests and monogenic testing, the women with moderate to high risk of developing breast cancer can be identified before the screening age of 50 years. With a personalised screening programme, some women may need to screen earlier and more often, while others can go to screenings less frequently in the future,” Kruuv-Käo explained. 

Estonia is already preparing for the introduction of a personalized breast cancer screening program, and the plan is to launch it this year. Will Norway follow? 

The post Polygenic risk scores: a European cancer priority  first appeared on Oslo Cancer Cluster.

The research group OSCAR (short for Osteosarcoma and CAR) consists of Nadia Mensali, PhD; Sany Joaquina, MSc; Sébastien Wälchli, PhD, and Else Marit Inderberg, PhD.

New targeted therapy against osteosarcoma

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A new cancer treatment against osteosarcoma has been developed in the labs of Oslo Cancer Cluster Incubator.

A new target for CAR therapy against osteosarcoma has been discovered in the Translational Research Unit at the Department of Cellular Therapy (Olso University Hospital). The results of their research, which was completed in the laboratories of Oslo Cancer Cluster Incubator, were recently published in an article in Nature Communications.

“CAR is a new type of molecule. It stands for Chimeric Antigen Receptor. It is part of a bigger family of cancer treatments called immunotherapy, in which you use the immune system of the patient to fight cancer,” explained Sébastien Wälchli, who has co-led this research project with Else Marit Inderberg.

A unique molecule

Chimeric antigen receptor therapy (CAR T) is a cancer treatment in which a patient’s T cells (a type of immune cell often referred to as the “foot soldiers” of the immune system) are changed in the laboratory so they will attack cancer cells.

“In the case of the CAR, we help the immune system to recognize cancer cells by putting in a completely artificial receptor. The key part of the receptor is the recognition site, so it will guide the immune cell to the tumour. Normally, we need a molecule that can recognize a cancer marker. The molecule of choice is an antibody,” said Wälchli.

The antibody that Wälchli’s group used was first isolated by clinical researcher and sarcoma expert Prof. Øyvind Bruland in 1986.

”We designed the CAR based on this antibody by using its coding sequence. This antibody is quite unique because it recognizes the marker on the surface of lung metastasis of osteosarcoma. We created a Osteosarcoma CAR (OSCAR) molecule to see if we could use the power of this antibody in immunotherapy and the results published in Nature Communications prove that we can,” explained Wälchli.

A full preclinical validation

The preclinical development of the treatment took place in the laboratories of Oslo Cancer Cluster Incubator which are fully equipped for such a process.

“We did a full preclinical validation of OSCAR using devices installed at the incubators for the in vitro and further tested it in vivo using different animal models where we mimicked what would happen in human. Our colleagues in Barcelona tested the injection of tumour cells directly into the bone of mice and observed a lower progression of cancer in the mice treated with OSCAR T cells, than we,” said Wälchli.

Furthermore, the group did experiments to check the toxicity of OSCAR T cells.

“We tried to predict using different healthy tissues if this CAR would only recognize tumour cells and spare healthy tissues. We concluded that it was safe, but before you inject it in human, you will never know for sure,” said Wälchli.

What is osteosarcoma?

Osteosarcoma is a bone cancer and affects many children and older people. It is quite well-treated with chemotherapy, but when it metastasizes to the lungs, it becomes more difficult to treat. Surgery can slow down the progression, but the cancer can reappear.

“This is where our hearts brought us. We are not choosing cancer by patient. We always talk with the clinicians. When we first discussed with Bruland, we did not know much about osteosarcoma. He told us about patients who have absolutely no alternative,” Wälchli explained.

There are other CARs in development against osteosarcoma globally, and some have already reached clinical phase, but none cover all patients.

“In the seminal paper of Bruland in 1986, they checked the biobank and estimated that 90 per cent of all osteosarcoma patients were positive to this antigen. This was confirmed by our collaborators in Spain. According to the first estimate, it looks like this marker is the most important that has been described so far,” said Wälchli.

The post New targeted therapy against osteosarcoma first appeared on Oslo Cancer Cluster.

Annbjørg Falck presented the Norwegian company NaDeNo during the International Cancer Cluster Showcase 2023.

Oncology innovators presented in Boston

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Three Nordic start-ups pitched at the International Cancer Cluster Showcase 2023.

This year’s International Cancer Cluster Showcase (ICCS) featured 20 emerging oncology companies that presented their recent innovations, partnering and investment opportunities on 5 June 2023 in Boston, as a satellite event to BIO International Convention. 

The companies were selected by innovation hubs in the United States (Massachusetts & Philadelphia), Quebec, Norway, the UK Golden Triangle, Switzerland, France, and Taiwan. 

“BIO International Convention is one of the largest gatherings of biotechnology and life sciences professionals from around the world. It provides an excellent platform for companies to network with potential partners, investors, customers, and collaborators. Via being part of the ICCS program emerging oncology companies get special visibility and exposure at the start of BIO. For those searching for collaboration, partnering and investment opportunities ICCS is an efficient format to meet 20 companies from international hubs and learn about their latest science, technologies, and (mostly preclinical) assets,” commented Jutta Heix, Head of International Affairs, Oslo Cancer Cluster and coordinator of the ICCS programme. 

Jutta Heix, Head of International Affairs at Oslo Cancer Cluster, welcomed the audience to the 12th International Cancer Cluster Showcase.

Promising Norwegian companies

NaDeNo, Hemispherian and One-Carbon Therapeutics represented the Nordic region during the event, which included four-minute pitches from each company. 

“Attending the BIO International conference for the first time as a small Norwegian start-up we highly appreciated the opportunity to share our story to a larger audience! Being visible in this way accelerates new relationships and valuable networking, and it really kick-started the conference for us. Many thanks to OCC for giving us this opportunity,” commented Annbjørg Falck, CEO and co-founder of NaDeNo.  

Adam Robertson, CSO of Hemispherian, presented one of the Nordic companies.

“The International Cancer Cluster Showcase presents a tremendous opportunity for Hemispherian to showcase our pharmaceutical development program on a global stage. This international exposure serves to highlight the exceptional nature of our technology and the expertise of our team. We are thrilled to have the privilege of presenting alongside other outstanding companies, which also provides us with a platform to showcase the rapidly growing Norwegian biotechnology sector. The event allows us to further establish Hemispherian’s reputation, attract attention to our innovative approach, and foster collaborations in the fight against cancer,” commented Adam Robertson, CSO of Hemispherian. 

Returning to Boston

This was the 12th edition of the International Cancer Cluster Showcase. Since 2012, the event has presented about 200 oncology start-ups and biotech companies as a satellite event to BIO International Convention and now returned to Boston where this format was started. The event connects emerging oncology companies from different innovation hubs with potential partners from the global oncology community gathering at BIO. 

The International Cancer Cluster Showcase 2023 was organized by Cambridge Innovation Partners, Montréal InVivo, The Wistar Institute, Oslo Cancer Cluster, OBN, Biopôle and Matwin. 

The event was kindly sponsored by Precision for Medicine, BIO and The Wistar Institute. 

 

 

The post Oncology innovators presented in Boston first appeared on Oslo Cancer Cluster.

Anette Weyergang, Senior scientist at Oslo University Hospital, talked to investors in Oslo Cancer Cluster Incubator. Photo: Sofia Linden / Oslo Cancer Cluster

Cancer start-ups met investors

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US healthcare and life science investors wanted to learn about Norwegian cancer companies.

Cancer entrepreneurs caught the attention of investors from the USA when they introduced their innovative ideas at a meeting in the Oslo Cancer Cluster Incubator last week.

“I was impressed by the Norwegian healthcare infrastructure and local entrepreneurial talent, which together serve as a catalyst for start-up innovation in the cancer field and wanted to learn more about how others can collaborate with this unique and world-class ecosystem,” commented Sandeep Vardhan, Managing Director at Kalpesh Ventures, one of the investors at the meeting.

The speakers were put to the test to present their companies in under five minutes. Topics ranged from novel drug targets in cancer immunotherapy and clinical decision support tools to machine-learning on colonoscopies and real-world evidence to accelerate drug development.

Taking ideas to market

“Competent investors is often key to success. That knowledgeable US investors invest time and energy in Norwegian cancer innovation and want to learn about the companies in the Oslo Cancer Cluster Incubator is a good sign. It is our job to connect start-ups with global investors and life science networks – so that they can succeed with taking their ideas to market,” commented Ketil Widerberg, CEO of Oslo Cancer Cluster Incubator.

Maria C. Lundstad Aulie was also at the meeting in her new role as Investment Manager Health and Life Sciences Oslo, Invest in Norway, Innovation Norway.

“I am excited about the interest shown in the Norwegian life science industry. An Alumina group from Colombia University, consisting of nine investors and entrepreneurs with competence and interest in health and life science, recently came to Norway to learn more about our health landscape. I am happy to work together Oslo Cancer Cluster to help follow up on every potential lead that can strengthen our health ecosystem. This visit was also a great start as I just started a new position working with the US market as well as with international investments into the health and life science industry in the bigger Oslo region,” commented Aulie.

See the presenters below:

Andreas Petlund, CEO of Augere Medical.

 

Christian Jonasson, Research Director of NordicRWE.

 

Bjarte Håvik, Project Leader at Western Norway University of Applied Sciences.

 

Ernest Aw, Research Manager and Business Developer of Thelper.

 

Mark Tyrell, Chief Medical & Executive Officer at Vitae Evidence.

 

The post Cancer start-ups met investors first appeared on Oslo Cancer Cluster.

Styret i HealthCatalyst AS består av lederne i de 3 klyngene - styreleder Arild Kristensen (NSCC), Ketil Widerberg (OCC) og Lena Nymo Helli (NHT). Photo: HealthCatalyst

Forenkler testing av helseteknologi sammen

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Two men and a woman looking into the camera

The following article is in Norwegian. It is about a new collaboration agreement between NorTrials Medical Equipment and HealthCatalyst with the aim to develop Norway as a test nation for health technologies. Please visit the Health Catalyst website if you want more information about the initiative.

NorTrials Medisinsk utstyr har inngått en samarbeidsavtale med HealthCatalyst AS for å utvikle Norge som testnasjon for helseteknologi.

Akselererer innovasjon i helsesektoren

HealthCatalyst AS er et samarbeid mellom de tre norske helseklyngene Norwegian Smart Care Cluster, Oslo Cancer Cluster og Norway Health Tech. Selskapet har som mål å bygge et ledende globalt test- og innovasjonssenter som utvikler Norges posisjon som en unik testside for fremtidens helse- og teknologitjenester.

HealthCatalyst AS er et non-profit selskap som eies med like deler av de tre klyngene. Selskapet vil bidra til økt konkurransekraft og økt verdi for den norske helseindustrien. Selskapet vil også bidra til å akselerere innovasjonsprosessen fra ide til marked for å skape robuste selskaper innen digital helse, medisinsk robotikk, og innenfor kunstig intelligens (AI). Dette vil bidra til å tiltrekke store utenlandske aktører til å legge test/utviklingsoppdrag i Norge.

NorTrials er et samarbeid mellom regionale helsemyndigheter og organisasjonene for legemiddel- og medisinteknisk industri, etablert på oppdrag fra Helse- og omsorgsdepartementet i 2021. Målet med NorTrials er å styrke og effektivisere kliniske studier i Norge gjennom å tilby et samarbeidsnettverk mellom ulike aktører i helse- og forskningssektoren.

Medisinsk utstyr er helt sentralt i det meste av diagnostikk og behandling av pasienter i sykehusene. Kliniske studier i forskning, utvikling og utprøving av medisinsk utstyr (teknologi) er noe de fleste sykehus driver med i større eller mindre grad, enten i egen forskning, samarbeidsprosjekter med universiteter og forskningsinstitutter, eller i samarbeid med industri. NorTrials Medisinsk utstyr er lagt til St. Olavs hospital HF.

Testkonsept for digitale løsninger

Samarbeidet mellom HealthCatalyst AS og NorTrials Medisinsk utstyr vil blant annet omfatte et felles kontaktpunkt for brukere der bedrifter, helsepersonell og forskere kan ta kontakt og få hjelp til det videre løp. Det vil også innebære utvikling av testkonseptet for digitale løsninger, inkludert forretningsmodeller, post market evaluering og tjenestemodeller. Internasjonal markedsføring vil også være en del av samarbeidet.

For å sikre at samarbeidet utvikler seg som begge parter ønsker, vil det etableres en styringsgruppe og en arbeidsgruppe. Arbeidsgruppen vil ha ansvaret for å definere konkrete oppgaver og aktiviteter for samarbeidet og legge til rette for at samarbeidet utvikler seg positivt. Det vil utvikles en strategi med handlingsplan for samarbeidet.

Milepæl for norsk helseteknologi

Dette samarbeidet vil være en milepæl for norsk helseteknologi og vil bidra til å øke Norges posisjon som en testnasjon for helseteknologi. Det vil også være et viktig bidrag til å utvikle norsk helseindustri og skape nye arbeidsplasser.

 

Foto: Thor Nielsen

 

Thomas Langø, faglig leder NorTrials Medisinsk utstyr. Foto: Nortrails

 

Jan Gunnar Skogås, senterleder NorTrials Medisinsk Utstyr. Foto: Nortrials

The post Forenkler testing av helseteknologi sammen first appeared on Oslo Cancer Cluster.

General Manager Ketil Widerberg (to the left) and Chairman of the Board Øyvind Kongstun Arnesen (to the right) welcomed the new Board Member Ingvild Stenstadvold Ross after the General Assembly 2023. Leif Rune Skymoen was not on-site when the picture was taken. Photo: Sofia Linden / Oslo Cancer Cluster.

Oslo Cancer Cluster strengthens the board

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Patient and industry perspectives are key as new board members join Oslo Cancer Cluster.

Ingrid Stenstadvold Ross, CEO of the Norweigan Cancer Society, and Leif Rune Skymoen, general manager of the Association of the Pharmaceutical Industry in Norway (Legemiddelindustrien – LMI) were voted into the board of Oslo Cancer Cluster at the General Assembly in May 2023.

Both newcomers bring a strong focus on the development of Norwegian health industry and collaboration between public and private partners – to improve patient’s lives.

Helping cancer companies

“I am grateful for this trust and look forward to starting the work in the board of Oslo Cancer Cluster. The most important issue for me is to contribute to the development of Norwegian health industry that creates new solutions and treatments for future patients.

“We need to work so the incredibly important cancer companies in the cluster get the best circumstances going forward. This means a special focus on the development of the Radiumhospital Campus and to secure that Norwegian companies in cancer get maximal opportunities through the EU Mission on Cancer, as well as, to use my experience in communication and political advocacy to influence the framework for the Norwegian health industry,” commented Ingrid Stenstadvold Ross.

Stenstadvold Ross has worked in the field of cancer for almost 10 years and has almost 20 years of experience in political advocacy, organisational development, and leadership within different NGO’s. Ross is also deputy chairman of the board of Abelia, and chair of the board of the European Fair Pricing Network.

Putting Norway on the map

“Oslo Cancer Cluster has through many years been an important driver for collaboration between different actors in the cancer field and an energic ambassador for Norway internationally. I am thankful for this opportunity to contribute to that research and development in the Norwegian cancer milieu benefits even more patients. And to build a new industry in a field where Norway has an extraordinary opportunity to succeed,” Skymoen commented.

Leif Rune Skymoen, general manager of LMI.

Skymoen has held several leadership roles in the Norwegian health industry, including Country Director for Eli Lilly Norway, CEO of Nansen Neuroscience, and co-founder and CEO of Curida.

 

The post Oslo Cancer Cluster strengthens the board first appeared on Oslo Cancer Cluster.