From left to right: Peder, Henrik, Isha and Christofer are very happy with the placement at the research group Experimental Cancer Therapy. Photo: Elisabeth Kirkeng Andersen

Advanced microscopy on the timetable

The Ullern students visited the Core Facility for Advanced Light Microscopy at Oslo University Hospital.

This article was first published in Norwegian on our School Collaboration website.

How can we learn more about cancer cells by using advanced microscopes?

A microscope is an important tool for scientists in many different branches of research. In February, four first-year students from the Researcher programme at Ullern Upper Secondary School got to test multiple different microscopes at the Core Facility for Advanced Light Microscopy, The Gaustad node, at Rikshospitalet (Oslo University Hospital).

Isha Mohal, Peder Nerland Hellesylt, Christofer Naranjo Woxholt and Henrik Eidsaae Corneliussen are sitting in a small, rectangular room, which belongs to the research group Experimental Cancer Therapy at Oslo University Hospital.

“If you sit next to me, you can see better what I am doing,” says Emma Lång to the students.

Emma Lång is a researcher at the research group Experimental Cancer Therapy. She explains to Henrik and Isha how the advanced microscope, connected to the computer behind her, can record videos of living cells. Photo: Elisabeth Kirkeng Andersen

Emma Lång is a researcher in the research group Experimental Cancer Therapy. She explains to Henrik and Isha how the advanced microscope, connected to the computer behind her, can record videos of living cells. Photo: Elisabeth Kirkeng Andersen

It is the second day of the work placement for the Ullern students. Lång will show them how she is setting up a very special microscope with the somewhat cryptical name “ImageXpress Micro”.

The microscope is so special that it is the only one in the entire Oslo region and Eastern Norway. The unique thing about the microscope is that it creates videos of thousands of living cells over a long time period. This enables the researchers to understand more about how the cells move.

This is important knowledge in the research on cancer and wound healing, which this research group is working on.

The students sit down beside Lång and follow what she is doing closely. The microscope is entirely automatic, so all the settings are done on a computer. Later the same day, the students will use the microscope themselves to record videos of cells that they have been working on from the day before.

Learning from practical work

This is the first work placement for the students from the Research programme – and they are really enjoying it.

“It is fun to see what the researchers are doing and to try it out ourselves in practice,” says Peder.

“We have done some work with pipettes and worked in the laboratory at school, so we are already familiar with some of the practical handiwork. It is fun to try it out in a real research setting,” says Isha.

She likes that the placement gives some insight into what a career in research and cellular biology can be like.

“I am more interested to work in cellular biology after this placement, but I haven’t decided anything yet. I think we are learning things in an exciting way. It is practical learning and not as theoretical as it is usually in school,” says Peder.

“I absolutely see this as an opportunity to become a researcher. It is great to have so much science subjects as we have on the Researcher programme,” says Henrik and Isha agrees.

“I am very interested in the natural sciences. We have a lot of theory in school and it is fun to come out into the hospital and into companies to see how researchers work – and to try it out ourselves,” says Isha.

Christofer also thinks it is interesting, but he is more interested in data and other general subjects.

“That’s great, Christofer,” Lång says. “Research needs more people with good data knowledge. Do you see the computer over there? It costs NOK 100 000 and it will be used to develop machine learning and a technique called ‘deep learning’ on the data produced from our microscopes. Maybe in a few years time, computers will be analysing the microscope images and videos that we are recording now.”

Images of cells

Yesterday, Isha, Peder, Christofer and Henrik worked on cells in the laboratory. They learned a technique to fixate cells. Then, they coloured the cells with antibodies that turn blue when they bind to the core of the cell and with a protein called actin that turns green. Actin performs several functions in the cell, it is both inside the cell structure and functions as threads of communication between the cells.

Stig Ove Bøe leads the research group was visited by the four students from the Research programme at Ullern Upper Secondary School for two days. Here, he is preparing the images of skin cells that the students worked on the day before. Photo: Elisabeth Kirkeng Andersen

Stig Ove Bøe leads the research group that was visited by the four students from the Research programme at Ullern Upper Secondary School for two days. Here, he is preparing the images of skin cells that the students worked on the day before. Photo: Elisabeth Kirkeng Andersen

Now, the students are looking at the results uploaded to a computer in an advanced image editing software program that can visualise the cells as two- or three-dimensional.

“These are the skin cells you coloured yesterday. Can you see that the cells make up one close network? The reason for this is that it is skin and it is supposed to be impenetrable. Can you also see that the single cells act differently at the edge than closer inside? It is our job to explain why and how,” Bøe explains to the students.

The students look and nod with interest.

After the placement, researchers at Rikshospitalet (Oslo University Hospital) have worked more on the images and videos that the students created.

These have been delivered to the students and will be used when they make a presentation of the placement and everything they learned to the rest of the students at the Research programme.

You can see the cell image below.

A three-dimensional image of the skin cells that the students have coloured. Photo: Emma Lång

A three-dimensional image of the skin cells that the students have coloured. Photo: Emma Lång

What is cell migration?

The research group “Experimental Cancer Therapy” led by Dr Stig Ove Bøe at Rikshospitalet are researching how cells move, which is called cell migration in scientific terms.

Cell migration plays a central role in many of the body’s physiological functions, such as the immune system and wound healing. Cell migration is also essential for cancer, since cancer cells can spread from the location of the tumour to other organs of the body.

Cells use different mechanisms to migrate. They can move as single cells or they can move collectively. Thousands of cells can, for example, cooperate so they can move in the same direction.

The research group uses many different microscopy-based methods to research cell migration. They are also developing new video methods to study living cells in microscopes.

The research group is also responsibly for the daily running of the Core Facility for Advanced Light Microscopy at Oslo University Hospital. The facility gives other research groups in the Oslo region access to and guidance of the use of advanced microscopy equipment.

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Gustav Vik (to the left) from Kjellervolla school and Martin Dimov from Mailand school are collaborating in the laboratory to isolate T cells. Photo: Bente Prestegård.

Research talents learned about immunotherapy

Gustav Vik from Killevold school and Martin Dimov from Mailand school are enjoying the gatherings arranged by Talentsenteret for realfag: “This is very interesting because we are learning things that are not part of the curriculum and we like to learn about current topics.”

This article was first published in Norwegian on our School Collaboration website.

A group of talented science students from Oslo and Akershus spent two days learning about immunotherapy from former cancer researchers, who are now teachers at Ullern Upper Secondary School and researchers at Thermo Fisher Scientific.

Collaboration partners: Oslo Cancer Cluster, Thermo Fisher Scientific Norway, Ullern Upper Secondary School, Norsk teknisk museum (The Norwegian Museum of Science and Technology) and Oslo Vitensenters Talentsenter i realfag (Talent centre for the natural sciences)

In February, 25 students from 19 different schools in Oslo, which are a part of “Talentsenteret for realfag” (Talent Centre for the Natural Sciences), arrived together to Oslo Cancer Cluster Innovation Park and Ullern Upper Secondary School.

The students were there to participate in a specially tailored two-day programme about medical research and the use of immunotherapy to treat cancer.

The days were spent partly in a classroom to learn about the theory of the immune system and partly in a laboratory to learn how to isolate a type of cells in the immune system called T cells. The method the students learned about is used in modern cell therapies against cancer, which are called CAR T therapies.

Gustav Vik from Kjellervolla School and Martin Dimov from Mailand School are enjoying the gatherings arranged by Talentsenteret for realfag: “This is very interesting because we are learning things that are not part of the ordinary school syllabus and we like to learn about current topics.”

Kaja Flote from Hellerasten school is looking in the microscope to find T cells. She thinks it is exciting to learn more about the depth of the immune system and how it can be changed to fight cancer. Photo: Bente Prestegård.

Kaja Flote from Hellerasten School is looking in the microscope to find T cells. She thinks it is exciting to learn more about the complexity of the immune system and how it can be changed to combat cancer. Photo: Bente Prestegård.

The next day, the students visited the production facilities of Thermo Fisher Scientific Norway, located in Lillestrøm. This is where the company makes Dynabeads (also known as “Ugelstadkulene” in Norwegian) to be used in five billion diagnostic tests every year and in CAR T therapies against cancer.

The Norwegian TV channel TV2 has produced this news segment about Emily Whitehead (link in Norwegian), the first child in the world who received CAR T therapy to treat her cancer, which was deemed incurable. The segment was recorded in 2019, when Emily and her family visited the Norwegian employees at Thermo Fisher Scientific in Oslo. Emily is today 13 years old and has been cancer-free for over eight years.

You can read more about the students’ experience at Thermo Fisher Scientific in this article from 2017, when another group of students from Ullern Upper Secondary School visited the same production facilities.

The researcher Morten Fure from Thermo Fisher tells the students about Dynabeads, also known as “Ugelstadkulene”, CAR T therapy, immunotherapy, and cancer. He has prepared T cell solutions that the students will look at in the microscope. Photo: Bente Prestegård.

The researcher Morten Luhr from Thermo Fisher Scientific tells the students about Dynabeads (also known as “Ugelstadkulene”), CAR T therapy, immunotherapy, and cancer. He has prepared T cell solutions that the students will look at in the microscope. Photo: Bente Prestegård.

The background to the collaboration

“Talentsenteret i realfag” (link in Norwegian) is a customised educational option for students who are especially strong academically. It is for those students who find that the standard school curriculum does not challenge them enough. Just like the school adapts the teaching for students who need extra help in subjects, they adapt the teaching for students who already know a lot and want to learn even more. This is a group of students with a high degree of motivation and a hunger for knowledge that is extraordinary.

The centre employs experts in different subjects to give the students the academic challenges they need. That is why this two-day programme in medicine and immunotherapy was held in February.

The programme was developed by employees from Thermo Fisher Scientific and two teachers from Ullern Upper Secondary School. Fet and Flydal Jenstad both have backgrounds as cancer researchers at the Institute for Cancer Research and the Institute of Cancer Genetics and Informatics respectively. Fet and Flydal Jenstad share the responsibility for the new researcher programme at Ullern Upper Secondary School. Read more about the researcher programme here (link in Norwegian).

Oslo Cancer Cluster and Ullern Upper Secondary School have a school collaboration project since 2009. The goal is to contribute to educating the researchers and entrepreneurs of the future.

Thermo Fisher Scientific is a global biotech company with strong Norwegian roots through the acquisition of the Norwegian biotech Dynal. Thermo Fisher Scientific is one of the members of Oslo Cancer Cluster and actively participates in the school collaboration between Oslo Cancer Cluster and Ullern Upper Secondary School.

Read articles about the other school collaborations Thermo Fisher Scientific have participated in:

 

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Moina Medbøe Tamuly (to the left) and his colleage Sondre Tagestad from NTENTION test the drone glove on Devon Island. Photo: Haughton-Mars Project

From Ullern to Mars

Moina Medbøe Tamuly (to the left) and his colleage Sondre Tagestad from NTENTION test the drone glove on Devon Island.

Read this article in Norwegian on our School Collaboration website.

A former Ullern student with an unusual career came to inspire current students in December.

Moina Medbøe Tamuly was in his final year at Ullern Upper Secondary School in 2014. Before Christmas in 2019, he came back to Ullern to tell today’s students about his exciting life after graduation.

Since Moina Medbøe Tamuly exited the school gates of Ullern Upper Secondary School for the very last time in June 2014, he has managed to spend two years in military service, worked in Trondheim, Oslo, Beijing, Shanghai, Amsterdam, Las Vegas, Brazil and the Arctic.

Moreover, he has an adventurous personality, combined with a passion for technology, which made him start the company NTENTION with his friend Magnus Arveng.

Magnus had the idea of a glove that could control drones, which he and Moina, together with their skilled team, has brought to life. The ground-breaking gloves can simplify the steering of everything from drones to VR interaction, music and robot arms. Their vision has been to develop a technology that is a natural and seamless extension of the human, instead of being an external instrument.

This has aroused the interest of the founder of the Mars Institute, Dr. Pascal Lee, who is collaborating with NASA on missions to the Moon and the exploration of Mars. The adventurous journey brought Moina all the way to Devon Island, a Mars-like, uninhabited island in the Arctic, together with his colleague Sondre Tagestad in NTENTION. During their stay, they tested if the glove could be used as an interactive instrument in conceptual space suits.

NTENTION’s collaboration partners at the Mars Institute/SETI Institute say in the article above that the glove “is revolutionary for future human exploration of the moon and Mars – and potential other planets”.

Right before Christmas 2019, Moina went back to his old upper secondary school, Ullern, to tell the students there today what life after graduation can be like.

Not a straightforward task

Moina tells the students the journey to Devon Island and the collaboration with astronauts has not been simple and straightforward, but has included many ups, downs and detours.

The students have brought their lunches into Kaare Norum auditorium to hear what the former Ullern student has to say about life after graduation.

Moina Medbøe Tamuly is back on his old hunting grounds, telling Ullern students about life after graduation.

Moina Medbøe Tamuly is back on his old hunting grounds, telling Ullern students about life after graduation. Photo: Elisabeth Kirkeng Andersen

At Ullern, Moina studied physics, history, philosophy and chemistry.

“I wasn’t very good at physics. I thought it was a really demanding subject, but also very exciting,” Moina says.

“After I graduated, I was really sick and tired of school. Then I had to do military service, something I wasn’t exactly thrilled about in the beginning. I was immature and created some disorder, but eventually I started liking it so much that I stayed there for two years. I was even accepted to The Royal Norwegian Naval Academy, which would have been an adventurous opportunity that I still daydream about sometimes.”

After the military service, Moina studied Industrial Economy and Technology Leadership at NTNU. In the passionate and teeming student atmosphere at NTNU, Moina met his business partner and friend Magnus Arveng and their company NTENTION was born.

Moina says that when he was a student at Ullern, he liked the subjects, the other students, the teachers and working for the student council. The first period at NTNU was a shock after such an enjoyable period of upper secondary school and military service.

“When I moved to Trondheim to study at NTNU, everything became chaotic. I had a breakdown and became depressed. It was a big transition from the military service, where I had great co-workers and a lot of responsibility, to academic studies. Our company saved me. It was pure magic to come back to an environment where you cooperate closely with one another to reach results together – and to be able to see the results of what you do every day,” Moina says.

Moina believes this is a reality many students can recognise and that it is important to learn that things don’t always go the way you planned, no matter how hard you work.

The company the students started together now has 13 employees in different roles and functions.

Doctor Pascal Lee, Head of the Research Station on Devon Island and space researcher at the Mars Institute is trying out the glove from NTENTION. Photo: Haughton-Mars Project

Dr. Pascal Lee, Head of the Research Station on Devon Island and space researcher at the Mars Institute, is trying out the glove from NTENTION. Photo: Haughton-Mars Project

The journey is as important as the goal

“I am not here to talk about what I have achieved, but about my life and the journey to get here,” Moina says to the Ullern students.

After showing the drone glove to interested students by using presentation slides and a video, Moina asks if there are any questions from the audience. Many hands go up in the air and they wonder how on Earth NTENTION got in touch with researchers that collaborate with NASA.

“It was very random. We met Dr. Pascal Lee at a conference arranged by Energy Valley. We knew the organisers and they gave us a stand for free. The glove we had developed can be used for music and art too. DJs can use it to play their set and combine it with video. So, together with the artist duo Broslo, we had arranged a unique stand with exciting artwork and video clips. That is where we started talking with Lee.”

A friendship developed between Lee, Moina and the others in NTENTION. Moina wants to highlight that you often meet friendly professionals if you dare to get in touch with them, one of the most important lessons from his journey so far.

“Our solution was a good fit with his visions and the need to explore Mars, so we began to work together,” Moina says.

The Ullern students’ lunch break is almost over, so Moina begins to sum up.

Devon Island is where NTENTION and Moina have tested the drone glove for the Mars Institute. Photo: Moina Medbøe Tamuly.

Devon Island is where NTENTION and Moina have tested the drone glove for the Mars Institute. Photo: Moina Medbøe Tamuly.

Time will be the judge of whether the drone glove Moina has developed one day will be a part of the space suits and equipment astronauts will use when landing on the Moon and Mars.

“The world will be more complicated and difficult when you graduate from Ullern, but all the more exciting. The last years of my life have been a little chaotic. It has been about closing deals and travelling around the world to find opportunities without a regular schedule. I finally learned that all people need to have a little bit of structure and to be part of a whole to thrive. In the end, I have unique experiences. My intellect has been nourished, I feel truly inspired and I am humbled to be a part of the journey where we are working to spearhead technological developments,” says Moina.

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Simone Mester, a cancer researcher at Oslo University Hospital, is mentoring students from Ullern Upper Secondary School. Photo: Elisabeth Kirkeng Andersen

Mentor meeting with Mester

Simone Mester mentoring students in the lab.

A few lucky Ullern students got to learn about cancer research from the PhD student Simone Mester at Oslo University Hospital.

The science and research programme at Ullern Upper Secondary School is completely new and the 32 students in the first class have received four mentors who will share their knowledge and experience with them. Early in December, the students were divided among the four mentors and got to visit them at their workplaces to hear more about what they do.

Simone Mester is a former student of Ullern Upper Secondary School and is today a cancer researcher at Rikshospitalet (Oslo University Hospital). Along with the three other mentors from the Oslo Cancer Cluster ecosystem, she has agreed to be a mentor for the students of the science and research programme at Ullern. Earlier in December, eight students visited her at her job.

“This is where I work,” Simone said as we arrived at the Institute for Immunology, which is located right next to Rikshospitalet.

Simone began the visit by telling the students about her background and the road that led her to where she is today.

Simone Mester tells Ullern students about how she started to do cancer research.

Simone Mester (above to the left) tell the Ullern students that she is part of the SPARK programme at the University of Oslo. Photo: Elisabeth Kirkeng Andersen

“I graduated from Ullern in 2012. That is when I got to do two work placements at the Radium Hospital – in Clinical Radiation Biology and Tumour Biology. That was the first time I got an impression of what everyday life for a researcher can be like and it was exciting!” said Simone.

She says that she combined the subjects mathematics, physics, chemistry and biology so that she would be able to study medicine. But as the application date drew closer, she became more and more unsure.

“I talked with Ragni, who is your teacher too, and she recommended that I study molecular biology at the University of Oslo. At the time, I didn’t fully understand what I was getting myself into and especially why I had to study all that physics,” said Simone.

During the course of her bachelor degree, Simone was still unsure and spent a lot of time with advisers at the Institute of Biology to get guidance on the best way forward. She decided to study a master degree and was included in a research group led by professors Inger Sandlie and Jan Terje Andersen, where she remains today as she is completing her PhD.

Researching new cancer medicine

“During my master degree, I wrote about how to tailor the duration of the effect of medicines and pharmaceuticals, and that is what I am still researching in my PhD. A lot of my time here is in the laboratory, where I am planning and conducting experiments on cells and mice, to see if I can achieve what I want,” Simone said.

“Now, I will show you what I spend most of my time on. It is about making proteins, so now I will show you the principal, and afterwards you can try to do the same in the lab. Moreover, you will meet a master student, Anette Kolderup, who will tell you about CRISPR,” said Simone.

CRISPR is short for “clustered regularly interspaced short palindromic repeats”. It is a family of DNA sequences found within the genomes of prokaryotic organisms, such as bacteria and archaea.

Quickly and pedagogical she shows the students the principals for modifying proteins through DNA modification, growing, amplifying and splitting cells.

“Now we will go to the lab, so you can try this yourselves,” said Simone.

We go one floor up, where there are offices and laboratories. The four girls go to Anette, who will show them what CRISPR is and how she uses the method in her master thesis, while the boys will start in the cell lab to make the same experiment that Simone just showed them.

Caption: Aleksander tries pipetting when he is working in the lab together with Simone. It is important to have a steady hand.

Aleksander tries to handle the pipette when he is working in the lab together with Simone. It is important to have a steady hand. Photo: Elisabeth Kirkeng Andersen

“Inside this hood, the work environment is completely sterile, so you need to wear lab coats and sanitize all the equipment and keep it inside the hood while we are working,” Simone explained.

Aleksander is the first to try and Simone shows him step by step how he can retrieve the proteins from a bottle she has prepared. Everyone soon understands that lab work is a craft that requires skillful hands. It is important to stay focused and remember which solutions that should be added and how, and when the pipettes should go on or off. Aleksander laughs when he has to change an unused pipette that he has touched, even with gloves on it is not allowed.

Then the students switch places and everyone gets to try their hands at everything. Two hours pass by quickly and a very happy group of students with their teacher Ragni leave to go home again.

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Students from the media and communications program at Ullern Upper Secondary School helped to create the podcasts Radium and Utbytte at the DNB Nordic Healthcare Conference 2019.

Students helped create podcast

Students at the DNB Nordic Healthcare Conference.

Our school collaboration project inspires science and health communication.

Ullern students were thrown head first into a live work environment this week. They gave technical assistance to the making of the podcasts Radium and Utbytte at the DNB Nordic Healthcare Conference 2019.

All the students are currently studying the media and communications program at Ullern Upper Secondary School, including a class on sound design. As an extra subject, they also started their own youth companies Marconi Media UB and Audio Mind UB.

Radium held a podcast marathon together with the DNB podcast Utbytte at this year’s conference, with six different sessions, interviewing CEOs and investors. Throughout the day, the Ullern students were expected to sound check, record, and edit the podcast – all on their own.

The students attended a planning meeting one week earlier. They also arrived the evening before to rig the set: a glass studio in the middle of the conference area.

The participants in the podcast Radium and Utbytte at DNB Nordic Healthcare Conference 2019 in the glass studio.

The Ullern students helped to rig the podcast studio the night before the conference.

“It is a really nice experience, because we are thrown into the real word and do things in practice,” Andrea Asbø Dietrichson from Marconi Media UB explained. “We have to do everything ourselves, even though we are beginners, but we are learning!”

“It has been interesting to hear what they are talking about (in the studio) and learn how it is to work during such a big event,” Theo Rellsve from Audio Mind UB added. “It is the largest event we have been to, with lots of people and things happening all the time. We are happy to take part!”

Ullern students recording the podcasts Radium and Utbytte at DNB Nordic Healthcare Conference

The Ullern students had to think on their feet to solve problems while recording the podcast.

 

The aim of the school collaboration project between Ullern Upper Secondary School and Oslo Cancer Cluster is to inspire students to develop their talents. One aspect of the project is to give students a taste of what real working life is like.

“Personally, I would like to work in media,” Andrea said. “It is really inspiring to be here. Media and communications is a broad subject, but sound design is something not a lot of people know.”

“Audiomind has a clear vision about our future as a company. We are happy that we can get this experience and use it towards developing the company further,” Theo said. “… And create the best podcast recording company in Norway.”

Elisabeth Kirkeng Andersen, Communications Specialist for Radforsk and one of the persons behind the podcast Radium, was very satisfied with the work the students had performed. She gave them a top score.

“They have everything under complete control,” she said. “It is really fun to see their learning curve. They only studied sound design for a few months, but they have already helped at two live shows and they are always calm and service-minded.”

Student helping in the glass studio.

Elisabeth Kirkeng Andersen was impressed by how helpful and service-minded the students from Ullern were.

Want to find out more?

 

Professor Kjersti Flatmark introduces the Ullern students to different cancer treatments, with a focus on colon cancer, during a theme day at Ullern Upper Secondary School. Photo: Elisabeth Kirkeng Andersen

Who wants to be a doctor?

A cancer doctor speaking to a room of students.

We join forces with Ullern Upper Secondary School and Oslo University Hospital every year to arrange theme days for students, so they can get a sense of what it is like to be a doctor.

On 18 November 2019, students from the health program with specialisation in biology and chemistry at Ullern Upper Secondary School, gathered in Kaare Norum Auditorium at Oslo Cancer Cluster Innovation Park to learn more about opportunities in medicine. The initiator is Truls Ryder, father of a former student at the school. Ryder is a surgeon at the Norwegian Radium Hospital and has this year once again planned theme days for the students together with his colleagues.

For almost five hours, the Ullern students listened to some of the best oncologists in Norway talk about how they treat cancer patients affected by different forms of cancer. The students are studying either science or health subjects in their third year.

The theme day is a part of the close collaboration between Ullern Upper Secondary School and the Norwegian Radium Hospital, Oslo University Hospital. For two days, 18 of the students who consider applying to medical or nursing school will follow the oncologists around the different departments of the Norwegian Radium Hospital.

“The students who have been chosen to job shadow are in their last year and will soon choose their next program of study,” Bente Prestegård said. She is the project manager for the school collaboration between Ullern Upper Secondary School and Oslo Cancer Cluster.

The purpose of the job shadowing is that students who participate will get an inside look into the opportunities that exist in medical subjects before choosing what to study next.

A fantastic initiative

Truls Ryder is the initiator behind the theme day and the following job shadowing, like he was last year. His children have gone to Ullern Upper Secondary School and he works as an attending physician at the Norwegian Radium Hospital.

“Thank you to the initiator Truls Ryder and his colleagues who have dedicated two days for this. It was really successful last year and we are incredibly happy to be able to offer the students this opportunity again,” Prestegård said.

Prestegård has contributed to the planning of the theme days with her long experience from other projects between members of Oslo Cancer Cluster and the school.

You can read about last year’s theme day and job shadowing here.

A varied program

The theme day today was spent in Kaare Norums Auditorium from 11:30 am to 4:00 pm. During these hours, the students have gained an in-depth introduction to modern cancer treatments, from radiology to plastic surgery, and what it is like to be a cancer patient and receive treatment.

“I look forward to the program myself, because there are many skilled experts, who will present what they do in cancer treatment and more. The goal with such a broad program is to give the students the greatest possible understanding of all the different directions and opportunities that medical study can offer,” said Ryder.

Program (Monday 18 November 2019):

11:30-11:55 Welcome, with Attending Physician Truls Ryder

11:55-12:20 Cancer treatment with focus on colon cancer, with Professor Kjersti Flatmark

Break

12:30-12:55 “Fight HPV” with Attending Physician Ameli Trope from Kreftregisteret

12:55-13:20 What is anesthesiology? with Professor Ulf Kongsgaard

Break

13:40-14:05 Melanoma, with Attending Physician Anna Winge-Main

14:05-14:30 Plastic surgery – more than just cosmetics! with Head of Clinic and Attending Physician Kim Tønseth

Break

14:40-15:05 Radiology – More than just x-rays! with Attending Physician Marianne Fretheim

15:05-15:30 What is it like to be a patient? with Jeanett Hoel, Chairman of the Norwegian Gynaecological Cancer Society and Attending Physician Kristina Lindemann

15:30-15:45 Summary and practical information concerning clinical rotation, with Attending Physician Truls Ryder

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From left to right: Simone Mester, PhD student at UiO, Øyvind Kongstun Arnesen, CEO of Ultimovacs, Jonas Einarsson, CEO of Radforsk and Janne Nestvold, Laboratory Manager at Oslo Cancer Cluster Incubator, met the Ullern students of the researcher program.

Meet the mentors

The mentors of the student research program at Ullern Upper Secondary School meet the students for the first time.

Read the questions and answers from when the students at Ullern Upper Secondary School met their mentors for the very first time.

In the middle of October, 32 students at the researcher program at Ullern Upper Secondary School got to meet their four mentors for the next year. After a short introduction, there were many questions from the students to the mentors. It took an hour and a half before their curiosity settled down and it was time for pizza.

Simone Mester: “I am a former student of Ullern Upper Secondary School and now I am doing a PhD in molecular biology. In the long term, I could imagine working in the private sector developing pharmaceuticals.”

Øyvind Kongstun Arnesen: “I am a doctor and worked many years in Lofoten. After that, I worked some years as a surgeon in an emergency room, before I began working for a large German pharmaceutical company called Boehringer Ingelheim. Eight years ago, I became CEO for Ultimovacs. Ultimovacs are trying to develop the worlds first cancer vaccine.”

Jónas Einarsson: “I am a doctor, and did the first part of my medical degree on Iceland, because my grades weren’t the best. Then, I worked many years as a general practitioner in Lardal, before moving to Oslo and becoming the manager of the first private hospital in Norway. In parallel with this, I did a degree in economy and management at BI. Finally, I became the CEO of Radforsk, who among other things, initiated the Oslo Cancer Cluster Innovation Park and this school collaboration.”

Bjørn Klem: Bjørn is the fourth mentor, but he was unfortunately ill during the first meeting. Janne Nestvold, Laboratory Manager at Oslo Cancer Cluster Incubator, came in his place. Nestvold has a PhD and has worked as a researcher for many years.

 

After the introductions, the teachers at the researcher program, Ragni Fet and Monica Flydal Jenstad held a short presentation of the upcoming work with the mentors.

Then, there were several questions from the audience.  We were really impressed by the amount and quality of the questions, that concerned both education, job opportunities and, research and development, which both Kongstun and Mester are a part of. The questions rained down and the answers came in a session that continued for over an hour and a half. You can read some of them below. Then it was time for some pizza and mingle.

The next time the students and the mentors will meet will be in the beginning of December. The students will meet in the mentors’ workplaces and see with their own eyes what they do on an everyday basis.

 

Questions and answers:

What kind of medical specialisation does Jónas and Øyvind have?

“We are both general practitioners and have not specialised. You do not have to.”

 

What kinds of jobs can you do after you are finished, Simone?

Simone: “I can do a postdoc to become a researcher in academia. I am still a student while I am doing my PhD, but I receive a salary. It is normal to do two postdocs, then you can become group leader or professor. I don’t think I will follow that route, I would much rather work in a private company or start something myself. I think that seems more exciting.”

Jónas: “Simone will get a job immediately in one of our companies if she wants it.”

 

Are there many developments every day to find a cancer vaccine?

Jónas: “It takes time, so the short answer is no.”

 

What is the greatest challenge with the cancer vaccine that Ultimovacs are developing?

Øyvind: “To make it work? A good and difficult question.”

Øyvind explained further about the development and testing of the vaccine at Ultimovacs.

 

What is your PhD about, Simone?

Simone: “I develop technology that prolongs the half-life of medicines. It is a patient-focused PhD, since it is a big inconvenience for the patient to take medicines often, but I hope we can succeed in prolonging the half-life so that patients can take the medicine once a week or once a month.”

 

What should one study if one wants to work with medical development or pharmaceutical development?

Jónas: “Molecular biology, physiology, IT, physics, chemistry, biology, statistics  – there are many opportunities.”

Øyvind: “In our company, we have physiologists, doctors, protein chemists, dentists and pharmacists working right now.”

 

When you went to upper secondary school, did you know that you would be doing what you do today?

Jónas: “I chose the natural science, but did not know anything else.”

Øyvind: “I only knew I wanted to study natural science.”

Simone: “I was thinking about studying a medical degree, but I am happy that I chose molecular biology.”

Janne: “I thought about becoming a researcher and thought it seemed exciting. You should absolutely think widely and not just the easiest solution when you are still in upper secondary school. You will benefit from that when you begin to study at university.”

 

Have you always been interested in biology, or was there something special you saw that made you excited about it? 

Jónas: “Yes, always.”

Øyvind: “Biology in itself is very fascinating. There is so much we do not know, like where memories are stored in the brain, for example. We know very little about how the body works, so that is very fascinating.”

 

The cancer vaccine you are developing, will it work against all cancers or only specific types of cancer?

Øyvind: “It will work to treat and protect against most cancer types.”

 

What did Bjørn do in PhotoCure, the company he worked for before becoming manager for Oslo Cancer Cluster Incubator?

Jónas: “He was Head of Research. He is a very smart guy, and he has also worked a lot with the regulatory side.”

 

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Thermo Fisher Scientific Norway was one of many stops during the guided tours through Oslo Cancer Cluster Innovation Park for students of Ullern Upper Secondary School.

A peak into the cancer research world

ThermoFisher Scientific Norway lectures students at Ullern

Ullern Upper Secondary School is unique, because it shares its building with world-class cancer researchers. Last month, all new Ullern students got to experience this first-hand.

This year’s School Collaboration Days in Oslo Cancer Cluster Innovation Park were held right before the autumn holiday. All the first-year classes at Ullern Upper Secondary School were given a guided tour around the Innovation Park to get to know the companies that they share their everyday lives with.

The purpose of the School Collaboration Days is to give the first-year students at Ullern Upper Secondary School an understanding of what the different companies in the Innovation Park and departments of Oslo University Hospital do.

The common denominator for all of them is cancer and many are developing new cancer treatments. While the Cancer Registry of Norway are collecting statistics and doing cancer research, Sykehusapotekene (Southern and Eastern Norway Pharmaceutical Trust) produce chemotherapy and antibodies for patients that are admitted to The Norwegian Radium Hospital and the Department of Pathology (Oslo University Hospital) gives the cancer patients their diagnoses.

 

IN PICTURES

The student guided tours of Oslo Cancer Cluster Innovation Park

Jonas Einarsson lecturing to students at Ullern

True to tradition, Jónas Einarsson, CEO of the evergreen fund Radforsk, opened the School Collaboration Days in Kaare Norum auditorium with a common lecture. In this image, Einarsson is talking about the development of the Montebello area, which Oslo Cancer Cluster Innovation Park is a part of. The first Radium Hospital was opened in 1932 and the following year Ullern School was moved from Bestum to the same place that houses Oslo Cancer Cluster Innovation Park today.

 

Kreftregisteret lecturing to students at Ullern.

Elisabeth Jakobsen, Head of Communications of the Cancer Registry of Norway, tells the first year students about what they do and the risk factors for developing cancer. Also, she asked the students several questions about how to regulate the sales of tobacco, e-cigarettes and many other things.

 

Thor Audun Saga is the CEO of Syklotronsenteret (“the Norwegian medical cyclotron centre”). He told the students about what they do, what a cyclotron is and how they use cyclotrons to develop cancer diagnostics.

 

ThermoFisher Scientific Norway lectures students at Ullern

The management of Thermo Fisher Scientific Norway are also housed in the Oslo Cancer Cluster Innovation Park. They told the students about the Norwegian invention called “Ugelstadkulene”. This is both the starting point for million of diagnostic tests across the world and revolutionary (CAR T) cancer treatments, 45 years after they were invented.

 

Students guided through the Oslo Cancer Cluster Incubator Laboratory

The tour was ended with a walk through the laboratory of the Oslo Cancer Cluster Incubator. The students were given an inside look at the work done and instruments used by the cancer researchers in the lab. This area is only one or two floors above their regular class rooms. The student could see first-hand the opportunities there are in pursuing a career in research, entrepreneurship and innovation.

From left to right: Bente Prestegård, Project Manager at Oslo Cancer Cluster, Henrikke Thrane-Steen Røkke, student, Peder Nerland Hellesylt, student, and Ragni Fet, Teacher at Ullern Upper Secondary School are happy to see the launch of the researcher program.

Educating the cancer researchers of tomorrow

Bente Prestegård from Oslo Cancer Cluster and Ragni Fet from Ullern Upper Secondary School with two of the students in the research program.

Ullern Upper Secondary School and Oslo Cancer Cluster are paving the way for students to become the researchers of the future.

A new program has been launched this autumn for Ullern students who wish to learn how researchers work. It will qualify students for university studies and specialise them in biomedical research, technology and innovation. It is the only researcher program for upper secondary school in Norway.

“The researcher program at Ullern will be a place where students are encouraged and guided to become independent students, with a need to explore, an understanding of methods and a desire to learn,” said Ragni Fet, teacher at Ullern Upper Secondary School. “They will learn to gather good and reliable information, they will do research in practice through varied experiments, and they will gain real insight into job opportunities in the research industry.”

The program is a joint initiative between Oslo Cancer Cluster and Ullern Upper Secondary School, who have been collaborating since 2009. This has offered students in the natural sciences, health, media and electricity special opportunities to learn science subjects outside a traditional classroom setting.

“The purpose of launching a researcher program at Ullern Upper Secondary School is to recruit the researchers, scientists and entrepreneurs of the future,” said Bente Prestegård, Project Manager at Oslo Cancer Cluster. “We know that these jobs are needed, and we want to teach students about what it means to be a researcher or entrepreneur. With better insight into the professions, the students will be able to make a safe career choice.”

 

With a passion for science

About 30 students have already begun this unique program at Ullern Upper Secondary School. One of them is Henrikke Thrane-Steen Røkke.

“I chose the researcher program because I personally enjoy studying the natural sciences and innovation, and I wanted more of those subjects. I had entrepreneurship as an elective at secondary school and thought it was a lot of fun. I think it seemed very exciting and wanted to learn more,” Henrikke explained. “I hope I can gain insight into what it is like to work as a researcher. I hope we can see and experience a lot of it in practice and to work in depth with some subjects in certain areas.”

The program is especially well suited for students with an interest in the natural sciences, such as Peder Nerland Hellesylt, who also recently begun the program.

“I applied to this program because I have always had an interest for the natural sciences and mathematics,” Peder said. ”I think this program is very interesting because we aren’t just sitting and writing, but get practical tasks too, for example experiments.”

 

Mixing theory with practice

Ullern Upper Secondary School is located right next to The Norwegian Radium Hospital, The Institute for Cancer Research, The Norwegian Cancer Registry and the Oslo Cancer Cluster Incubator, with its over 30 big and small companies. The students are therefore never far from world class researchers. This offers the unique opportunity to take advantage of the co-localisation and use mentors from the research milieu in the teaching.

“Through the collaboration with Oslo Cancer Cluster, we will obtain external lecturers to the class rooms; bring the students to multiple, exciting innovation companies and laboratories; and the students will attempt real research experiments themselves. We are raising the level and are ambitious for the sake of the students,” Ragni Fet said.

 

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Emmy and Benedicte learned about research into neuroscience and how to use modern medical technology, such as CRISPR, when on work placement with researcher Marianne Fyhn and her colleagues at the University of Oslo. Photo: Monica Jenstad

Learning about the human brain

Oslo Cancer Cluster and Ullern Upper Secondary School arranged a work placement for students to learn about neuroscience at the University of Oslo.

Four biology students from Ullern Upper Secondary School spent two great days on work placement with some of the world’s best neuroscientists at the University of Oslo. In Marianne Fyhn’s research group, the students tried training rats and learned how research on rats can provide valuable knowledge about the human brain.

The Ullern students, Benedicte Berggrav, Lina Babusiaux, Maren Gjerstad Høgden and Emmy Hansteen, first had to dress in green laboratory clothes, hairnets and gloves. They also had to leave their phones and notepads behind, before enterring the animal laboratory where Marianne Fyhn and her colleagues work. Finally, they had to walk through an air lock that blew the last remnants of dust and pollution off them.

On the other side was the most sacred place for researchers: the newly refurbished animal laboratory. It is in the basement of Kristine Bonnevies Hus on the University of Oslo campus. We used to call it “Bio-bygget” (“the bio-building”) when I studied here during the ‘1990s.

 

Researcher Kristian Lensjø showed the four excited biology students into the most sacred place: the animal lab.

It is the second day of the students’ work placement with Marianne. The four biology students, who normally attend the second year of Ullern Upper Secondary School, have started to get used to their new, temporary jobs. They are standing in one of the laboratories and looking at master student Dejana Mitrovic as she is operating thin electrodes onto the brain of a sedated rat. PhD student Malin Benum Røe is standing behind Dejana, watching intently, giving guidance and a helping hand if needed.

“We do this so we can study the brain cells. We will also find out if we can guide the brain cells with weak electrical impulses. This is basic scientific research. In the long term, the knowledge can help to improve how a person with an amputated arm can control an artificial prosthetic arm,” Marianne explained.

“The knowledge can help to improve how a person with an amputated arm can control an artificial prosthetic arm.”

Dejana needs to be extremely precise when she connects the electrodes onto the rat’s brain. This is precision work and every micrometre makes a difference.

 

Training rats

The previous day, Maren, Benedicte, Lina and Emmy helped to train the rat on the operating table on a running course. Today, the Ullern students will train the other rats that haven’t had electrodes surgically connected to their brains yet.

“We will train the rats to walk in figures of eight, first in one direction and then the other”, the students explained to me.

We remain standing in the rat training room for a while, talk with Dejana and train some of the rats. Dejana tells me that the rats don’t have any names. After all, they are not pets, but they are cared for and looked after in all ways imaginable.

“It is very important that they are happy and don’t get stressed. Otherwise, they won’t perform the tasks we train them to do,” says Dejana. She and the other researchers know the animals well and know to look for any signs that may indicate that the rats aren’t feeling well.

“It is very important that they are happy and don’t get stressed.”

I ask the students how they feel about using rats for science.

“I think it is completely all right. The rats are doing well and can give us important information about the human brain. It is not okay when rats are used to test make-up and cosmetics, but it is a whole different matter when it concerns important medical research,” says Emmy and the other biology students from Ullern nod in agreement.

 

Understanding the brain

Marianne is the head of the CINPLA centre at the University of Oslo, where Maren, Benedicte, Lina and Emmy are on work placement for two days. Four other Ullern students, Henrik Andreas Elde, Nils William Ormestad Lie, Hans Christian Thagaard and Thale Gartland, are at the same time on a work placement with Mariannes research colleague, Professor of Physics Anders Malthe-Sørenssen. They are learning about methods in physics, mathematics and programming that help researchers to better understand the brain.

“CINPLA is an acronym for Centre for Integrative Neuroplasticity. We try to bring together experimental biology with calculative physics and mathematics to better understand information processing in the brain and the brain’s ability to change itself,” says Marianne.

Physics, mathematics and programming are therefore important parts of the researcher’s work when analysing what is happening in the rat’s brain.

If you think that research on rats’ brain cells sounds familiar, then you are probably right. Edvard and May-Britt Moser in Trondheim received the first Norwegian Nobel Prize in Medicine in 2014. The award was given to them for their discovery of a certain type of brain cells, so called grid cells. The grid cells alert the body to its location and how to find its way from point A to point B.

Marianne did her PhD with Edvard and May-Britt, playing an essential role in the work that led to the discovery of the grid cells. Marianne was therefore very involved in Norway securing its first Nobel Prize in Medicine.

 

The dark room

Another room in the animal section is completely dark. In the middle of the room, there is an enormous box with various equipment. In the centre of the box, there is a little mouse with an implant on its head.

In this test room, there is an advanced microscope. It uses a laser beam to read the brain activity of the mouse as it alternates between running and standing still on a treadmill.

The researcher Kristian Lensjø is back from a longer study break at the renowned Harvard University and will use some of the methods he has learned.

“I will train the mouse so that it understands that for example vertical lines on a screen mean reward and that horizontal lines give no reward. Then I will look at which brain cells are responsible for this type of learning,” says Kristian.

The students stand behind Kristian and watch the mouse and the computer screen. When the testing begins, they must close the microscope off with a curtain so that the mouse is alone in the dark box. Kristian assures us that the mouse is okay and that he can see what the mouse is doing through an infra-red camera.

“This room and the equipment is so new, we are still experiencing some issues with the tech,” says Marianne. But Christian fixes the problem and suddenly we see something on the computer screen that we have never seen before. It is a look into the mouse’s brain while it runs on the treadmill. This means that the researchers can watch the nerve cells as the mouse looks at vertical and horizontal lines, and detect where the brain activity occurs.

 

Research role models

The students from Ullern know they are lucky to see how cutting-edge neuroscience is done in real life. Marianne and her colleagues are far from nobodies in the research world. Bente Prestegård from Oslo Cancer Cluster and Monica Jenstad, the biology teacher at Ullern who coordinates the work placements, made sure to tell the students beforehand.

“This is a fantastic and unique opportunity for students to get a look into science on a high international level. They can see that the people behind the research are nice and just like any normal people. When seeing good role models, it is easier to picture a future in research for oneself,” says Monica.

“This is a fantastic and unique opportunity for students to get a look into science on a high international level.”

Monica and Marianne have known each other since they were master students together at the University of Tromsø almost twenty years ago.

“I know Marianne very well, both privately and professionally. She is passionate about her research and about dissemination and recruitment. She also works hard to create a positive environment for her research group. Therefore, it was natural to ask Marianne to receive the students and it wasn’t difficult to get her to agree,” says Monica.

Back in the first operating room, Dejana and Malin are still operating on the rats. They will spend the entire day doing this. It takes time when the equipment needs to be found and sterilised, the rats need to be sedated and then operated on as precisely as possibly. It is past noon and time for lunch for Marianne, Kristian and the Ullern students on work placement.

Before I leave them outside Niels Henrik Abels Hus at the Oslo University Campus, I take a picture to remember the extra-ordinary work placement. And not least: to store a picture of the memory in my own brain.

 

Finally, time for lunch! From the left: Emmy Hansteen, Benedicte Berggrav, researcher Marianne Fyhn, Lina Babusiaux, Maren Gjerstad Høgden and researcher Kristian Lensjø. Photo: Elisabeth Kirkeng Andersen.

 

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