Ketil Widerberg, general manager of Oslo Cancer Cluster, gave input to the hearing on the changes to the Biotechnology Act in order to promote cancer innovation in Norway.

Research on gene-edited embryos allowed

Important cancer research into gene-edited human embryos will now be possible in Norway

Research on gene-edited human embryos will now be allowed in Norway, after a majority agreement has been reached among parties in the Norwegian Parliament. The news was given at a press conference on Thursday, when representatives from the three political parties Arbeiderpartiet, Fremskrittspartiet and Sosialistisk Venstre presented the amendments to the Biotechnology Act (“bioteknologiloven”). This is the act relating to the application of biotechnology in medicine.

The changes to the Biotechnology Act are good news for cancer patients and researchers, as they allow for research into gene-edited human embryos. This will give us important knowledge about how cancer arises and how to develop effective treatments against cancer.

Oslo Cancer Cluster gave input to these changes, during a hearing on 6 February 2020 at the Ministry for Health and Care Services. We emphasised that it is important that the regulations are in line with technological developments to promote research, so that we in the future have improved access to personalised cancer diagnostics and treatments.

“These are important changes to promote cancer innovation in Norway. It will help accelerate research into new cell therapies, which will benefit cancer patients both here in Norway and abroad,” said Ketil Widerberg, general manager of Oslo Cancer Cluster.

Gene technology is an important area in cancer research, with many recent break-through discoveries. By gene-editing human embryos, researchers can develop personalised cancer treatments and diagnostics.

Cell division in embryos and uncontrolled cell division in cancer cells is regulated by the same genes. That is why research on gene-edited human embryos will give us valuable knowledge about genetic diseases like cancer.

Gene technology can be used to create genetic changes and give us more knowledge about cell division. For example, researchers can insert genetic markers in DNA and follow the cell’s development from stem cell to cancer cell. They can also produce mutations in an embryo and study how cancer develops at an early stage.

You can read more about cancer research and gene-editing on the Cancer Research UK Science Blog.

It is important to note that the embryos used for research and gene-editing are not allowed to be implanted in a female uterus for pregnancy. This is in line with the current Swedish regulations on gene-edited human embryos.

The fact that gene-editing human embryos will be allowed in Norway means that we can attract world-class cancer clinical studies and deliver new personalised treatments to cancer patients.

The Norwegian Parliament (“Stortinget”) will officially vote on the amendments on 26 May 2020 and we will follow any further developments closely.

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Foto: Helsenæringens Verdi 2020

Helsenæringens verdi 2020

Helsenæringens Verdi 2020

Helsenæringen er en dobbel mulighet for Norge: næringen kan løse mange av våre helse- og omsorgsutfordringer de neste tiårene og samtidig bli en av våre største næringer, med eksport til et globalt marked.

Den norske helsenæringen hadde en samlet omsetningsvekst på 4,7 prosent i 2018. Rapporten dokumenterer at denne veksten særlig var drevet av store selskaper i den norske helseindustrien. Bedriftene i alle bransjene i helsenæringen rapporterer om ytterligere vekst 2019, noe som resulterer i et vekstestimat for næringen som helhet på 6,2 prosent for 2019 – dette er høyere enn næringens gjennomsnittlige årlige vekst for de siste ti årene.

Bedriftene rapporterer samtidig om svært sterke forventninger til treårsperioden fra 2020 til 2022. Bedriftenes egne vekstprognoser for disse årene er imidlertid hentet inn før Koronakrisen utviklet seg til en global krise. Det er av den grunn svært høy usikkerhet knyttet til disse prognosene.

Koronakrisen er en «helsekrise». Dette gjør at krisen påvirker helsenæringen med en langt større variasjon mellom bransjer og segmenter enn for andre næringer. I rapporten redegjøres det både for segmenter i helsenæringen som aldri har opplevd høyere etterspørsel og aktivitet enn nå under Koronakrisen samt for bransjer og segmenter som har tilnærmet stoppet helt opp.

Den norske helsenæringen fremstår som godt forspent for videre vekst også i etterkant av Koronakrisen. Krisen har bidratt til å rette fokus på beredskap og innenlandsk produksjonskapasitet. En trend mot dette er ventet å styrke selskaper og produksjonsland som kan levere kvalitet, profesjonalitet og trygghet for leveranser, også i krisesituasjoner. Dette er en trend som bør kunne gagne Norge og norske helsebedrifter, både produsenter av legemidler eller medisinsk teknologi så vel som leverandører av helsetjenester.

Helsenæringens verdi 2020 dokumenterer at det er særlig er to ting bedriftene etterspør for å sikre videre vekst,

  • Markedstilgang – bedriftene i helsenæringen, både industri- og behandlingsbedriftene, trekker frem tilgang til offentlige anbud og konkurranse på like vilkår som den største flaksehalsen for videre vekst. Det er særlig mindre bedrifter og selskaper med inntekter fra både inn- og utland som opplever tilgangen på offentlige anbud som dårlig.
  • Skaleringskapital – det trekkes frem av et flertall av bedrifter at de savner støtteordninger som er innrettet mot skalering og internasjonalisering

Se lanseringen av Menon-rapporten

Les rapporten Helsenæringens Verdi 2020

Aktørene som står bak Menon-rapporten:

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Computers with different software and programming language is necessary to learn about machine learning and artificial intelligence. PhD student Øyvind Sigmundsson Skøyen explains to Jakob, August, Magnus and Jørgen how to program the game Snake so that the snake always survives.

Programming to understand artificial intelligence

Students learning Artificial Intelligence, Machine Learning and Neural Networks

This article was originally published in Norwegian on our School Collaboration website.

How can programming, artificial intelligence and machine learning help us understand the human brain?

Four students from Ullern Upper Secondary School spent two days in the beginning of March on a placement in the Department of Physics at the University of Oslo. Jakob, August, Jørgen and Magnus learned how to program the snake in the game Snake to survive. At the same time, they learned about artificial intelligence, neural networks and machine learning.

Every spring, Professors Anders Malthe-Sørenssen and Marianne Fyhn at the University of Oslo receive eight students from Ullern Upper Secondary School on a placement.

Marianne Fyhn’s research group consists of some of the leading neuroscientists in the world. The four biology students Chiara, Eline, Tora and Eilin from Ullern Upper Secondary School spent the placement training rats and learned how research on rats can provide valuable knowledge about the human brain.

Anders Malthe-Sørenssen is the Director of CCSE (the Center for Computing in Science Education), where the students Magnus Trandokken, August Natvik, Jørgen Hamsund and Jakob Weidel were on another placement.

“There are three PhD students here, who are teaching the Ullern students. At the end of the day, they will gain a better understanding of what artificial intelligence is. We wish to explain the concept to them and give them an insight into what machine learning, neural networks and programming are,” said Malthe-Sørenssen.

  • Scroll to the bottom of this page to read the definitions for machine learning, neural networks and artificial intelligence.

Malthe-Sørenssen and the PhD students tested a new teaching tool on the Ullern students. If it is successful, more students will be able to access it to learn about artificial intelligence. Malthe-Sørenssen and his research group also try to improve the teaching of advanced mathematics, physics and programming in upper secondary schools.

Students learning artificial intelligence, machine learning and neural networks

Øyvind Sigmundsson Skøyen (in the middle) was one of the PhD students that taught the students from Ullern Upper Secondary School. Here, he is helping Jakob Weidel, who is in his first year. To the right is August Natvik, who is graduating this year. Photo: Elisabeth Kirkeng Andersen

Making the snake immortal

Jakob, Magnus, August and Jørgen programmed the game Snake in the programming language Python. This is a programming language that is available for free, an “open source”. You can download it here.

The point of the game Snake is to keep a snake alive for as long as possible. It lives in a square, where it eats candy so that its tail grows. The purpose of the game is to make sure the snake doesn’t crash into itself while it is growing because if it crashes, the snake dies. But it is not that easy. Try it yourself here.

“The students will program the snake so that it can learn where it is smart to move to eat the candy, while at the same time avoiding to crash into its growing tail. It is a good way to understand a little artificial intelligence and machine learning,” said Malthe-Sørenssen.

The three PhD students Sebastian Winther-Larsen, Øyvind Sigmundsson Skøyen and Even Marius Nordhagen were there to teach the Ullern students.

Øyvind had just finished showing the students how to programme the snake when it was Even’s turn to teach.

“What du you already know about machine learning?” Even asked.

“I have seen a little bit on YouTube,” Jakob replied.

“I know the theory, but I haven’t tried it myself,” Magnus said.

Even explained that he would present the theories behind machine learning and neural networks first, and then let the students create a neural network for Snake.

“Linear regression – a theory we often use in mathematics – is a simple form of machine learning. It is about producing a function that gives us the best line between two points. We use something called the method of least squares,” Even said.

Ullern students learning artificial intelligence, machine learning and neural networks.

Espen Marius Nordhagen (to the right) explains to the students from Ullern that regression is a simple form of machine learning. August Natvik is following closely. Photo: Elisabeth Kirkeng Andersen

Even explained that machine learning is used in image analysis. A computer can be taught to recognise and see the difference between several objects in a picture. The objects can be cars, bikes, humans, or other things. The computer can then be taught to create the images, which are then called generative models. Voice recognition, such as the virtual assistant Siri for iPhone users, is also based on machine learning, just like self-driving cars and buses.

“In order to understand artificial intelligence, you have to know what a neural network is. The concept is inspired by biology, neuroscience, and how human beings learn and remember. A neural network is a simplification of the human brain. The brain is in reality much more complicated,” Even explained.

“What is actually the difference between machine learning and artificial intelligence?” Jørgen asked.

Even explained that regression is machine learning, but not artificial intelligence.

“If you have a neural network with several layers, a so-called ‘deep neural network’, it is artificial intelligence. Then you will observe that something is happening with the data you receive from the neural network, it will be something you do not understand and cannot model, but it is consistent with reality,” Even said.

Learned new subjects

Magnus, August and Jørgen are all in the third year and have specialised in the natural sciences, with different combinations of mathematics, physics, technology, research, programming and computer modelling.

After graduating, all three of them will go to military school. Afterwards, Jørgen and Magnus are tempted to study at NTNU.

“The Industrial Economics programme at NTNU seems really good. Maybe I will combine it with the Entrepreneurship Programme, which is also at NTNU. Then I can start my own company after I finished studying. I am also thinking about a career in the military,” said Magnus.

The Ullern students agreed that the placement at the Department of Physics had been difficult, but fun and educational too.

“They are really good at teaching here. It has been difficult, because we haven’t studied these subjects before and everything new is always difficult,” said Jørgen.

Jakob Weidel is still in his first year and is thinking about studying the same subjects as the other three Ullern students. He was asked to participate in the placement after he helped Tom Werner Halvårsrød, the IT administrator at Ullern Upper Secondary School, to programme Excel sheets, which are used in the school.

“I have made a few apps and developed a few websites and used different types of programming languages. I have never used Python before, so it has been fun to learn something new,” said Jakob.

(image caption) Anders Malthe-Sørenssen is a professor at CCSE (the Centre for Computing in Science Education) at the University of Oslo. He and his research group are active in many different areas of research, including improving how physics is taught and understanding how the brain works through advanced mathematical models. Photo: Elisabeth Kirkeng Andersen.

Anders Malthe-Sørenssen is a professor at CCSE (the Centre for Computing in Science Education) at the University of Oslo. He and his research group are active in many different areas of research, including improving how physics is taught and understanding how the brain works through advanced mathematical models. Photo: Elisabeth Kirkeng Andersen

Neural networks and neuroscience

Malthe-Sørenssen’s and Fyhn’s research groups collaborate in a field of biology and physics, which is about research into how the human brain works and neural networks, in the projects DigiBrain and CINPLA. CINPLA is an acronym for Centre for Integrative Neuroplasticity.

“Here at the Department of Physics, we create computer models of neural networks. Then, we compare our models with Marianne’s discoveries about how the brain works from her studies on rats and mice. So far, we have seen that our models give a good picture of what is actually happening in the brain, but we are far from finished,” says Malthe-Sørenssen.

His popular research group receives over 1 000 job applications every year, but they want to keep prioritising student placements.

“We are dedicated to contributing to improving the programming skills in schools. One of our employees has developed the new subject and the syllabus for programming and computer modelling, which will be implemented in upper secondary schools by autumn 2020. Programming will then be used to teach several subjects, including mathematics,” Malthe-Sørenssen says.

He thinks it is good to contribute to raising the level of skills in the local schools around the Department of Physics at the University of Oslo.

What is a placement?

Oslo Cancer Cluster and Ullern Upper Secondary School have an active school collaboration project. The collaboration gives students at the school the opportunity to take part in work placements at different companies and research groups at Oslo University Hospital, at the University of Oslo and with members of Oslo Cancer Cluster.

On the placements, the students get to learn about different subject areas directly from experts and they get the opportunity to do practical laboratory work. The purpose of the placements is to give the students an insight into the practical everyday life of different professions and what career opportunities that different academic degrees hold.

DEFINITIONS

Neural Networks: A neural network is a group term for data structures, and their algorithms, that has been inspired by the way nerve cells in the brain are organised. Neural networks are among the key concepts in machine learning and artificial intelligence.

Machine learning: Machine learning is a special area within artificial intelligence, where you use statistical models to help computers to find patterns in large data quantities. The machine “learns” instead of being programmed.

Artificial intelligence: Artificial intelligence is information technology that adapts its own activity and therefore seems intelligent. A computer that is able to solve assignments without instructions from a human on how to do it, has artificial intelligence.

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Our funding support: up to €60 000 per SME

Our EU project DIGI-B-CUBE offers funding support of up to €60 000 per SME, for small to medium-sized enterprises that may be struggling during the corona crisis.

The COVID-19 pandemic represents an unprecedented challenge for healthcare systems and societies worldwide. There is an urgent need for novel diagnostics solutions, integrated detection systems and biosensing technologies that would, in a rapid, specific and efficient way, support the identification and tracking of infection chains and acquired immunity. Biological and biomedical imaging technologies are also essential for addressing many research questions, such as those related to SARS-CoV-2 infections, from basic research at the molecular and cellular level to medical applications and diagnostics. In addition, Biobanking processes are crucial in the race towards a COVID-19 vaccine and development of treatment options.

There is an urgent need to support Small and Medium-sized Enterprises (SMEs) capable of delivering innovation projects addressing the broad range of COVID-19 related challenges.

Through DIGI-B-CUBE project, we are announcing our funding support for SMEs to fight against COVID-19 through cross-sectoral collaborative projects. DIGI-B-CUBE offers direct financial support up to €60,000 per SME from relevant sectors including healthcare, medicine, biotech, biopharma, IT, robotics, automation, electronics, and nanotech. DIGI-B-CUBE supports digital innovations and solutions for the reconfiguration of the Medical Diagnostics and related value chains (depicted in the diagram below) towards a Health Economy 4.0 with a special focus on Biobanking, Bioimaging, Biosensing and related industries.

digibcube graphics

Given below are the details of the DIGI-B-CUBE open call: 

Project Name: Digital Enterprise Innovations for Bioimaging, Biosensing and Biobanking Industries (DIGI-B-CUBE)

Open Call Title DIGI-B-CUBE Open Call for Proposals for Innovation Projects (DIGI-B-CUBE-IA-2020-2021)

Open Call Publication Date: 22 April 2020

Deadlines:

Voucher Type 1st Deadline 2nd Deadline
Prototyping Voucher 29 July 2020 at 17:00 (CET) 03 February 2021 at 17:00 (CET)
Customised Solution Innovation Voucher 29 July 2020 at 17:00 (CET) 03 February 2021 at 17:00 (CET)
Continuous Open Call
Co-working Disruption Lab Voucher From 28 October 2020 to 27 October 2021, 17:00 (CET)

Expected Duration of Participation:

Voucher Type Project Runtime
Prototyping Voucher 1 to 3 months
Customised Solution Innovation Voucher 2 to 6 months
Co-working Disruption Lab Voucher 0.5 to 2 months

Maximum Funding Request per Proposal:

Voucher Type Max. funding per SME Max. funding per project
Prototyping Voucher €20 000 €60 000
Customised Solution Innovation Voucher €50 000 €150 000
Co-working Disruption Lab Voucher €10 000 €10 000

Purpose of the Vouchers and Respective Applicant Group:

Voucher Type Purpose Applicant Group
Prototyping Voucher Support to prototype or conceptualise a solution (proof of concept, feasibility study) for a digitalization challenge in the Medical Diagnostics and related value chains. Consortium consisting of minimum 2 SMEs and maximum 3 organizations;

From at least 2 different sectors (Example: An SME from healthcare/medicine/biotech/biopharma + An SME from IT and related sectors)

Customised Solution Innovation Voucher Support to jointly develop a novel product/service based on an existing proven concept that addresses a digitalization challenge in the Medical Diagnostics and related value chains. Consortium consisting of minimum 2 SMEs;

From at least 2 different sectors (Example: An SME from healthcare/medicine/biotech/biopharma + An SME from IT and related sectors)

Co-working Disruption Lab Voucher Support to further advance a successfully completed customised solution innovation voucher project in an incubator / accelerator / co-working space of the DIGI-B-CUBE clusters’ network (or) in labs, technical and innovation facilities of other relevant SMEs. One SME from a completed Customized Solution Innovation Voucher project consortium + a host organisation (host does not receive direct funding from this voucher)

Evaluation Process:

The evaluation process takes max. 4 weeks starting from the respective cut-off date/deadline. The applicant/s will receive an e-mail about the outcome of the assessment directly after the assessment is finalised.

Target Group:

SMEs from the following sectors are eligible to apply for DIGI-B-CUBE vouchers:

  • healthcare / medicine / biotech / biopharma
  • IT and related sectors (robotics, automation, electronics, nanotech etc)

Submission Language: English

Web address for full open call informationhttps://digibcube.eu/open-calls/

Web address for proposal submissionshttps://digibcube.eu/collaborative-platform/

E-mailinfo@digibcube.eu

Indicative budget for the call: Total budget €2 700 000. The following budget planned across the deadlines may change based on the number and quality of the applications received.

Voucher Type 1st Deadline 2nd Deadline
Prototyping Voucher approx. €360 000 approx. €240 000
Customised Solution Innovation Voucher approx. €1 050 000 approx. €700 000
Continuous Open Call
Co-working Disruption Lab Voucher approx. €150 000

Contact (Coordinator):

Dr. Gupta Udatha

Director (Digital & EU)

Oslo Cancer Cluster

Oslo, Norway

Email: gupta.udatha@oslocancercluster.no