Meet our new members

Image of Oslo Cancer Cluster Innovation Park

Say hello to the four new members that have joined our cluster organisation this year.

Oslo Cancer Cluster works to accelerate the development of novel cancer diagnostics and treatments, to improve patients lives.

Our member base comprises university hospitals, research centres, patient organisations, start-ups and biotech companies, global pharma and technology companies, investors, financial institutions as well as service providers – all working in the cancer field. Jointly, they cover the entire oncology value chain, from exploratory research to delivering novel therapeutics and diagnostics to patients worldwide.

This week, we talked to the four newest members about what they do and why they joined our cancer eco-system.

 

Nadeno – improving cancer treatments

Yrr Mørch, CTO and Co-founder, and Annbjørg Falck, CEO and Co-founder, Nadeno.

“NaDeNo is developing a vehicle for delivery of ‘hard to deliver’ drugs with great potential for improved cancer treatment. We are focused on developing new treatment solutions for patients with ‘hard to treat cancers’ and we aim to deliver effective drugs of low water solubility safely to the cancer cells by using our nanoparticle technology.

“Oslo Cancer Cluster offers a highly valuable international network for Norwegian biotech companies within the oncology space, and we see the OCC as a trusted partner that can help us progress our development.”

Annbjørg Falck, CEO and Co-founder, Nadeno

 

Hjernesvulstforeningen – advocating for patients

Rolf J. Ledal, Secretary general, The Norwegian Brain Tumour Association

“Hjernesvulstforeningen, The Norwegian Brain Tumour Association, is a patient advocacy organisation covering all the different diagnosis of brain tumours. We are involved in research as well as peer to peer support, learning patients and their families cognitive strategies for living well with such an disease and political lobbying for longer and better lives.

“Our motivation for being a member of Oslo Cancer Cluster is to connect with a broader variety of companies and research facilities who together will be able to make new discoveries within treatment options. We have the patient experts that the research community need to cooperate with to solve the many puzzles that still is unsolved. Brain cancer is on the top of diagnosis with poor outcome, together we are going to change that.”

Rolf J. Ledal, Secretary general, The Norwegian Brain Tumour Association

 

Node Pharma – developing radiopharmaceuticals

Tor Espen Stav-Noraas, CEO and founder of Node Pharma.

“Node Pharma is developing radiopharmaceuticals for metastatic cancer patients with limited treatment options. Our targeted drug compound is designed to eradicate tumors without damaging healthy tissue. This will save patients and improve quality of life after treatment.

“Oslo Cancer Cluster will bring important expertise, connections and enable us to accelerate our drug development.”

Tor Espen Stav-Noraas, CEO and founder, Node Pharma

 

Marigold Innovation – founding life science companies

Peter Horn, founder and CEO, Marigold Innovation

“One way Marigold Innovation can contribute is through our new approach to founding life science companies. We are co-founders, not advisors or consultants. We engage with researchers and innovators as early as possible to ensure everything is in place before company formation –  and then co-found the companies together with them.

“We’re originally from Denmark, but we think Nordic. We have founded companies in Sweden and our many connections here made Norway the obvious next step. The OCC community looks like a perfect match for a home in Norway.”

Nicholas Hawtin, Partner, Marigold Innovation

The post Meet our new members first appeared on Oslo Cancer Cluster.

Anita Tunold, CEO of Aleris, Torbjørn Furulund, Director of Health and Welfare, NHO Geneo, Kristine Sandvik, CEO of IF/Vertikal Helse and Ketil Widerberg, general manager of Oslo Cancer Cluster, participated in the panel conversation. Photo: Wenche Gerhardsen / Oslo Cancer Cluster

Kantar: Few Norwegians know about clinical trials

Almost 7 of 10 Norwegians don’t know about the opportunity to participate in clinical trials.

The annual report Helsepolitisk barometer (Health Political Barometer in English) from Kantar reveals what Norwegians currently think about health politics.

A main finding shows Norwegians do not know what clinical trials are or how to participate in them.

The report is based on a survey conducted with over 2 000 respondents, who are representative of Norwegian population over 18 years old.

Lack of awareness about clinical trials

The population has little knowledge of what clinical studies are, how they are accessed, and if it is a relevant treatment option when diagnosed with cancer.

More than a third of the respondents – 37 per cent – answered they do not know about the routines for clinical trials. In addition, 15 per cent answered, “I am not sure what a clinical trial means” and 16 per cent chose the option “I wouldn’t have known to ask about a clinical trial as a treatment option”.

“If patients don’t know about clinical trials, they won’t know to ask about it either. Clinical studies give access to new treatments. Today, many people don’t have access to clinical trials or don’t know about it. In practice, this creates a class divide,” commented Ketil Widerberg, general manager of Oslo Cancer Cluster.

The Norwegian population has little knowledge of what clinical studies are, how they are used and if this is an opportunity they have access to in case of a cancer diagnosis. Source: Extract from Helsepolitisk barometer 2023

The Norwegian population has little knowledge of what clinical studies are, how they are used and if this is an opportunity they have access to in case of a cancer diagnosis. Source: Extract from Helsepolitisk barometer 2023

 

Want more modern treatments

The government should prioritize the use of more modern cancer treatments with less side effects, according to 49 per cent of the respondents.

“Today, most cancer patients need to go through two or three standard-of-care treatments before they are evaluated for precision treatment. Can we as a society move the modern treatments, that precision medicine represent, further into first line of treatment? We need public-private collaboration to develop new cancer treatments to achieve this,” commented Widerberg.

In addition, 38 per cent think giving as good cancer treatment as our neighbouring countries should be the priority. The third most popular option was to prioritize offering more experimental treatment as part of standard care, chosen by 24 per cent of the respondents.

Treatments with less side effects and the same treatment options as our neighbouring countries, is what the voters think the government should prioritize. Source: Extract from Helsepolitisk barometer 2023

Treatments with less side effects and the same treatment options as our neighbouring countries, are the things voters think the government should prioritize. Source: Extract from Helsepolitisk barometer 2023

 

Calling for a Mission on Cancer

An overwhelming majority – 74 per cent – think a Mission on cancer would contribute to improving the lives of people affected by cancer.

“The European Union has launched a Mission on Cancer and set aside a significant amount of money for this. An important part of the Cancer Mission is prevention. Norway can spearhead how to work on cancer prevention and prevention of other diseases,” Widerberg commented.

74% think a mission on cancer will contribute to improving the lives of those affected by a cancer diagnosis. Source: Extract from Helsepolitisk barometer 2023

74 per cent think a mission on cancer will contribute to improving the lives of those affected by a cancer diagnosis. Source: Extract from Helsepolitisk barometer 2023

The post Kantar: Few Norwegians know about clinical trials first appeared on Oslo Cancer Cluster.

Photo: Curida

Learning from the Americans

Ole Dahlberg, CEO of Curida Diatec, reveals where he thinks the health industry is headed, why Norway needs to own its medical manufacturing, and how we might learn from the Americans.

“I wish that we can make things happen faster here in Norway. We can learn from the Americans that you don’t need to have all details in place to get going. If we commit to invest in the health industry, it will not go wrong.”

Ole Dahlberg is the new CEO of Curida Diatec. He has more than 25 years’ experience from the life sciences. He was Managing Director for Thermo Fisher Scientific Norway for eight years, and later Vice President for Thermo Fisher working out of California, USA. He has also co-founded three start-up companies, and sits on several boards, including Oslo Cancer Cluster, Nadeno, DoMore Diagnostics, and Caedo Oncology.

“If we commit to invest in the health industry, it will not go wrong.”

Why does this accomplished international business leader wish to invest his time in Norway?

“There is a lot of great research being done here, but it needs to translate to value creation for companies, and we need more commercial partners to help put products on the market.”

Is Norway prepared?

This is where Curida comes into the picture. Curida is a Norwegian company that helps biotech companies that want to scale up manufacturing, or that want to transfer their manufacturing and need help with quality improvement.

“Norway is at a crossroads when it comes to national preparedness.”

“Curida is at an inflection point right now and will need to make significant investments to upgrade. There is interest to invest in the company, especially from international investors. At the same time, Norway is at a crossroads when it comes to national preparedness. The government needs to make a strategic choice about which manufacturing processes they want to control. I hear many stakeholders calling for a clear direction from the government,” said Dahlberg.

A missed opportunity

Dahlberg has been in a similar situation before. When he was Managing Director for Thermo Fisher Scientific, the company together with Novartis wanted to invest in production facilities for cell therapies in Norway. There were already advanced laboratories in use at the Norwegian Institute of Public Health.

“This demonstrated we could do it. But we were not able to reach an agreement with the government on how to transfer technology and scale the business on reasonable terms.”

Instead, Thermo Fisher Scientific set up production facilities in Vilnius, Lithuania, where they received better support from the government. Today, the Vilnius site is scaling fast with 1 900 employees that are manufacturing world-class products and building sought after competence.

“The pandemic demonstrated the importance of manufacturing control and building key competence.”

“Back then it was less important to me as an international industry leader; I had to make the right decision for Thermo Fisher Scientific. As a Norwegian however, this was clearly a missed opportunity. The pandemic demonstrated the importance of manufacturing control and building key competence.”

Time to take a risk!

The health industry in Norway has grown rapidly the last decade. A new generation of up-and-coming researchers are eager to take a chance and create companies. More start-ups are spun out from research than before. There have already been successful examples of companies on the stock market.

“The problem is that many of the companies don’t scale. We need politicians to work closely with the industry and innovators. Politicians also need to enable cross-ministry collaborations and initiatives, and finally agree to a common purpose and a few goals. We have a good foundation in Norway with much experience in process industry, and tradition and reputation for our ability to work internationally.”

“We need politicians to work closely with the industry and innovators.”

Dahlberg also thinks the politicians should start promoting Norway as a place for international collaboration and technological innovation, as well as a country that attracts life science talents.

“Companies have difficulties finding the right talents. I think politicians should make sure students want to come here and that the networks attract more high-skilled people. We need both young and old, different nationalities and of all competencies. We must help talent immigrants manage the complex tax situation when they move to Norway.”

A Norwegian success story

Curida is one of the recent success stories from the Norwegian health industry. The company has had an incredible development over the last eight years, increasing its annual turnover from NOK 50 million in 2015 to NOK 200 million today. The company has already lined up agreements with international companies to increase that number significantly in the next 18 months.

“It is crucial for the Norwegian government to support the industry now if they want to have influence and necessary control on key manufacturing in Norway.”

“Curida is a fully owned Norwegian company, and it is no longer a start-up, but is scaling fast. We have signed new contracts and have more customers coming in. We will invest in new technologies, upgrade our production processes, build competence and organisation, and initiate great collaborations. It is crucial for the Norwegian government to support the industry now if they want to have influence and necessary control on key manufacturing in Norway,” said Dahlberg.

As difficult as landing a plane …

When it comes to manufacturing medicines, the tech transfer process is extremely time-consuming, complicated, and unpredictable. Projects can run out of time, costs can increase, and the customer might lose its window to the market or have to take existing products off the market.

At the Curida site in Elverum, there are over 130 employees spanning 20 nationalities, who all hold unique competencies in this field. Some of them have been with the company since its establishment almost 30 years ago.

“The highly skilled employees make Curida great at tech transfer. It is a bit like landing an airplane. There are a lot of moving parts, and many things can go wrong. Curida has done an impressive number of tech transfers and shown every single time that we can deliver on quality, time, and price.”

It is often in the tech transfer processes that small companies struggle.

“We do not have a traditional pharma industry, like in Sweden, and that is why we need to scale fast.”

“If the companies manage to do the right job and surround themselves with the right partners, they can quickly enter clinical phase. This is where Norway needs to expand the value chain. We do not have a traditional pharma industry, like in Sweden, and that is why we need to scale fast,” said Dahlberg,

A growing innovation milieu

Dahlberg has been on the board of Oslo Cancer Cluster for the last seven years and followed how the clusters have made an impact on Norwegian innovation.

“Oslo Cancer Cluster has been a pioneer in this field, with a clear oncology focus. They have started their own incubator and with their close connection to Radforsk Investment Fund, we see many exciting companies coming through the organisation. Oslo Cancer Cluster is an extremely important facilitator, represents diverse members and has become a well-recognized international brand.

“The challenge going forward will be to understand the value proposition to our members and listen closely to what they need. It is an exciting road we have ahead of us, and I look forward to contributing to the organisation’s future direction.”

The post Learning from the Americans first appeared on Oslo Cancer Cluster.

Photo: iStock

More personalised breast cancer screening

A new clinical pilot offers personalised breast cancer screening to Norwegian women.

A new clinical pilot will investigate how women can receive more personalised breast cancer screening. Currently, women in the age group 50-69 are invited to mammogram screenings every second year in Norway, but 20 percent of breast cancer cases are diagnosed among younger women.

“This ‘one size fits all’ approach does not take into account the different breast cancer risks of individual women. A more personalised screening program might be beneficial for both women and society, both in terms of increased surveillance of persons at higher risk for breast cancer, as well as more targeted use of resources. My motivation as a breast radiologist is to work for a high-quality, evidence-based screening program for breast cancer, and this study is an exciting contribution in that respect,” said Tone Hovda, senior radiologist at Vestre Viken Hospital Trust, where the study is running.

Tone Hovda, senior radiologist, Vestre Viken Hospital Trust

Using innovative DNA analysis

Participants of the study will submit a saliva sample, which is sent to Estonia for a genetic data analysis done by the Estonian medical technology company and healthcare service provider Antegenes that has developed the genetic test AnteBC. The AnteBC test is a CE-certified medical device.

The test is used to map a range of gene variants that individually don’t give increased risk for breast cancer, but where the combination of several genes can result in an increased risk. This is called polygenic risk score (PRS) and has never been used in screening programmes in Norway before.

Saliva shows risk of breast cancer

The results from the test will show if the participant has an elevated genetic risk for breast cancer. If it doesn’t, the participant will be recommended to follow the ordinary screening programme for breast cancer in Norway.

If the test shows an elevated risk for breast cancer, the participant will be offered a control scheme, which may include a recommendation of starting regular mammography before they turn 50 years old and/or go to mammography more often than every two years.

“The study analyses a woman’s genetic predisposition to the development of breast cancer, and based on that, provides personalized clinical recommendations for the prevention and early detection of disease. In the pilot study, both a woman’s polygenic risk and, if necessary, the presence of rare single genes that increase the risk of breast cancer will be evaluated,” commented Peeter Padrik, CEO, Antegenes.

Participants will also answer a questionnaire to give background information, such as family history. If there is suspicion of elevated risk of hereditary familial disease, the participant may be offered genetic counselling and extended genetic testing according to current clinical practice.

Towards personalised screening

This initiative is part of the implementation research project AnteNOR, which aims to investigate how it will be possible to implement a more personalised screening programme for breast cancer in Norway, based on the individual’s genetic risk for disease.

The project partners are Oslo University Hospital, the University of Oslo, Vestre Viken Hospital Trust, Oslo Cancer Cluster and Antegenes. It has received funding from The Norway Grants Green ICT programme and runs between 2021-2024.

The clinical trial has received approval from the regional ethics committee and is registered in the database clinicaltrial.gov.

Project partners:

Funded by:

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