Breakthrough Agreement for Phoenix Solutions

A new exciting collaboration among two Oslo Cancer Cluster members has been initiated. GE Healthcare has agreed to be the manufacturer of the target drug delivery platform ACT, made by Phoenix Solutions.

Early Christmas Present
As an early Christmas present to each other the two companies announced that they had signed an agreement securing manufacturing for ACT, short for Acoustic Cluster Therapy, a technology platform for targeted drug delivery. CEO at Phoenix Solutions, Per Sontum, emphasized the importance of gaining a manufacturer that had experience with similar products.

“We are excited to sign this agreement and get GE on board as contract manufacturer of our product. With more than 20 years of experience producing Sonazoid and Optison, GE`s Oslo organization is the world leading site for the manufacturing of this class of pharmaceuticals.”

From GE`s Womb
The collaboration, however, is not totally out of the blue. Phoenix Solutions sprung out from GE Healthcare in 2013. GE`s General Manager for Norway, Bjørn Fuglaas believes this tie between the two companies is an advantage:

“We are very pleased that Phoenix has chosen to work with GE for this project, which is in line with the expectations we had when the company was spun out of GE in 2013. This is an area of interest and we believe GE to be uniquely positioned in this field given existing and strong capabilities within production of disperse pharmaceuticals, and microbubbles in particular”, he says.

This agreement also secures what is called Good manufacturing practice (GMP) for Phoenix Solutions. Making their product and company a safer potential for investors and further along in their development than time should suggest.

A Very Promising ACT
ACT is a special and interesting targeting device. It is an ultrasound mediated drug delivery system that specializes in beating the vascular barrier. It has a wide range of therapeutically useful applications, but Its primary use being the ability to deliver sufficiently high concentrations of drug to the tumor without contaminating its surroundings. Phoenix thinks ACT is a promising targeting system for pancreatic, liver, triple negative breast and prostate cancers, and has extremely promising pre-clinical results so far.

Oncoinvent With New Lab and Bright Future

The cancer research company and Oslo Cancer Cluster-member Oncoinvent opened this Thursday a brand-new lab and research facilities at Nydalen Oslo. Now they control the whole production line and continue their development of their lead product candidate Radspherin.

A Good Year
2017 has been a good year for Oncoinvent. The company has now relocated and built new office and laboratory facilities, grown from four to twelve employees, and raised new capital. CEO at Oncoinvent Jan A. Alfheim believes that this represents a significant milestone for the company and will enable the company to further develop Radspherin®, a novel alpha-emitting radioactive microparticle designed for treatment of metastatic cancers in body cavities.

And Oncoinvent ends the year in fashion by opening brand new laboratory and research facilities. A lot of interested people came to tour the new facilities, observing an impressive lab with special infrastructure. Treating radioactivity, and circulating air in a facility that treats radioactive materials, calls for an extra advanced ventilation system.

Lab With all the Facilities
The idea of the new research facility is to be able to contain the whole production line, from research to drug manufacturing, to one location. All this contained in an area of 581 m2.

Creating a modern lab with the capabilities to treat radioactive materials in an active and well populated part of Oslo demands very strict guidelines. The production suites in the facility are constructed to be qualified for Good Manufacturing Practice (GMP) for production of Medical Product Candidates. Systems for purifying and monitoring of air and water quality as well as the removal of any potential radioactivity have been installed to ensure the safety of the operators, population and the environment.

The Production and Research areas of the laboratory will facilitate both the development of the Radspherin program and other discovery projects of the Company.

A Weapon for Precision Medicine
Radspherin® has been shown to cause a significant reduction in tumor cell growth an it is anticipated that the product can potentially treat several forms of metastatic cancer. Oncoinvent is developing Radspherin® as a ready-to-use injectable product that seeks out cancer tumors and destroys them from inside by emitting its radioactive content.

The first clinical indication for Radspherin® will be treatment of peritoneal carcinomatosis, a rare type of cancer that occurs in the peritoneum, the thin layer of tissue that covers abdominal organs and surrounds the abdominal cavity. Additionally, Oncoinvent has lined up a collaboration with European and American clinical research centers for the clinical development Radspherin®.

Four Cluster Companies Get Innovation Reward

Nacamed, Phoenix Soulutions, NorGenoTech and Clever Health are awarded Innovasjonsrammen for good early-stage innovation and collaboration. Innovasjonsrammen is awarded by Oslo Cancer Cluster with money from Innovation Norway. Congratulations!

Important with early financing
Early financing while companies are establishing their business is often limited, but can be crucial to get important projects off the ground. Therefore, Innovation Norway has given Oslo Cancer Cluster 1000 000 NOK to reward excellent innovation and collaboration activity at an early stage. A cluster is all about reaping the benefits of collaboration and Oslo Cancer Cluster has awarded the Innovasjonsrammen-money to four of their promising member companies. Hopefully this will inspire other potential financers to support Norwegian bio businesses at an early stage.

Prize money awarded
NorGenoTech AS     150 000 NOK
Clever Health           100 000 NOK
Phoenix Solutions    500 000 NOK
Nacamed                 150 000 NOK

Hanne Mette Kristiansen from Innovation Norway and Ketil Widerberg from Oslo Cancer Cluster, as well as Bjørn Klem form Oslo Cancer Cluster Incubator, handed out checks for Innovasjonsrammen. Her received by Sergey Shaposhnikov from NorGenoTech, Jon-Bendik Thue from Clever Health, Per Christian Sontum from Phoenix Solutions and Christina Westerveld Haug and Lars Gunnar Fledsberg from Nacamed.

Bringing Together Tech Knowledge
At the 5th floor of Oslo Cancer Cluster the four companies each received their innovation award handed out by Hanne Mette Kristiansen from Innovation Norway, Ketil Widerberg from Oslo Cancer Cluster and Bjørn Klem from Oslo cancer Cluster Incubator.

Ketil Widerberg, General Manager at Oslo Cancer Cluster, thanked Innovation Norway for providing the money and the panel of experts that helped pick the four deserved winners. – This money helps to remove some risk from the early stages of the innovation process, said Widerberg.

Bjørn Klem from Oslo Cancer Cluster Incubator added that it had been a very difficult process choosing the winners from the eight companies that applied. However, giving out prize money requires hard choices and he applauded the versatility at display.

–I think it is interesting that the four companies represent four different approaches within cancer research. Four different technologies. And getting them together here today is what Oslo Cancer Cluster and the incubator is all about: Getting different people together sharing knowledge and impulses!

Hanne Mette Kristiansen from Innovation Norway explained that Innovasjonsrammen was a way of reaching out to companies that usually avoided their attention. Startups that had not yet attracted any serious business attention, but nevertheless had very promising projects.

About the companies
Sergey Shaposhnikov from NorGenoTech explained that the money was coming in very handy. They are a company, as he explained it, straight out of the lab. Now they could start turning their research into business.

Clever Health has a more customer or patient oriented focus in their business model. Jon-Bendik Thue from Clever Health explained how a widespread disease as prostate cancer needs a way of differentiating between the patients that need treatment and the ones that do not.

Per Christian Sontum from Phoenix Solutions was very thankful for the award and money. He showed everybody how ultrasound can be way of targeting cancer cells with precision drug delivery.

And the event was elegantly rounded off by Christina Westerveld Haug and Lars Gunnar Fledsberg from Nacamed. Nacamed’s business goal is to produce nanoparticles of silicon material for targeted drug delivery of chemotherapy, radiation therapy and diagnostics to kill cancer cells. She explained that the money would be put in use straight away. Preparing for important trials after Christmas.

NOME Important to BioIndustry Growth

Nordic Mentor Network for Entrepreneurship (NOME) will be an important piece of the puzzle if Norway is going to fulfill their ambitions set by the coming White Paper on the Healthcare Industry.

If we are to make our bioindustry more competitive and take a leading European role within eHealth, we need to learn from the best in the business. NOME is a program that aims to lift Nordic life sciences to the very top by using mentors.

The Norwegian Parliament’s Health Committee has asked for a report on the Healthcare industry in Norway, a so called White Paper. The objective is to examine the challenges we face because of climate change, new technology, robotics and digitalization.

Innovation needs to meet industrial targets
Additionally, the committee has stressed the importance of a purposeful dedication to health innovation. There should be a focused investment In fields where we have special preconditions to succeed. A better facilitation of clinical studies and use of health data is especially emphasized. Nordic countries are in a unique position with vast registries of well documented health data, a good example being the Cancer Registry of Norway. With better implementing of new technology this type of health data will be increasingly important.

The committee also emphasized the need to shorten the distance between research and patient treatment through effective commercialization. And, in continuation, easier access to risk investment capital to help the industry grow.

–The path from research to actual treatments and medication is long and hard, and rightfully so – everything must be thoroughly tested. But you can imagine! Every second we can peel off the time it takes for new research to reach patients is extremely valuable and saves lives, explains Bjørn Klem, Managing Director, Oslo Cancer Cluster Incubator.

NOME a piece of the puzzle
However, how do we fulfill these ambitions? Klem believes the answer is combining forces within the other Nordic countries.

– We have different strengths. Think about how big Bioindustry and business is in Denmark. There is so much to learn form that!

NOME is a concrete way of collaborating. It is easy to say: “we are going to learn from each other”, but how do we in a concrete fashion set about doing this. NOME is a mentoring program that sets collaboration in motion.

— To put it plainly, NOME is a program for all Nordic Bio start-ups. They can apply and if their application is successful we send experts catered to help with the company’s very specific needs, explains Klem.

NOME is a meeting place between the start-up freshman and the experts that have thread this path before. They match Nordic entrepreneurs with handpicked international professionals to help each start-up with their specific needs.

— Think about it! There is so much a new start-up don’t know, lacking network and experience. How do you make it as a commercialized company in the health industry? NOME can provide both business and research mentoring transferring knowledge from past successes to new ones, says Klem.

A Twofold Benefit to Society
The desire is to propel the Nordic countries into one of the leading life science regions to commercialize high growth life science start-ups.

— With NOME society’s return is twofold. Firstly, we give patients access to new treatment faster by giving start-ups the necessary guidance and know-how. Secondly, we give our Bio Business a chance to grow with all the positives that has to economy and employment, Klem believes.

Oslo Cancer Cluster Incubator coordinates the NOME-program in Norway and collaborates with the incubator Aleap to find the best match of mentors and entrepreneurs. To take part in the program you can click here for more information.

Missed Us at Oslo Innovation Week?

Luckily, all our events at Oslo Innovation Week and Forskningsdagene are available for a rerun. Have a look!

We had great audiences during our three events on the 27th and 28th of September. If your were not among them, sitting in the brand new science centre of the Norwegian Cancer Society, do not despair. The events were all live streamed on Facebook. You still have a chance to experience them right here.

The events were co-hosted with our partners the Norwegian Cancer Society, the Norwegian Radium Hospital Research Foundation (Radforsk), IBM, Cancer Research UK, Norway Health Tech and EAT.

 

The first event of the week was titled “Antibiotic resistance and cancer – current status, and how to prevent a potential apocalyptic scenario”.

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Antibiotic resistance and cancer – Current status, and how to prevent a potential apocalyptic scenario #OIW2017

Posted by Kreftforeningen on Tuesday, September 26, 2017

 

Our secondary event had the title “Cancer research and innovation – benefit for patients”.

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Cancer research and innovation – benefit for patients #OIW2017

Posted by Kreftforeningen on Wednesday, September 27, 2017

 

The third and final event on our Oslo Innovation Week calendar was about how big data may transform the development of cancer treatments. 

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How Big Data may transform the development of cancer treatments #OIW2017

Posted by Kreftforeningen on Wednesday, September 27, 2017

Thermo Fisher Scientific Wins Innovation Award

The Research Council of Norway has given Thermo Fisher Scientific the prestigious Innovation Award for their Dynabeads.

 

The Oslo Cancer Cluster member Thermo Fischer Scientific was awarded the prize for developing an entirely new variant of an existing product, making it possible to analyse human genes quickly and effectively and improve diagnostic testing and patient treatment.

This is the technology known as «Dynabeads» that makes faster and cheaper DNA-sequencing accesible.

– The award means a lot to us as a company, and to everybody who has been working on product, production and launch during these years. It is an acknowledgement that investment, cooperation and important global products are noticed, says Ole Dahlberg, CEO at Thermo Fischer Scientific Norway.

Vital role in Norwegian biotech
Thermo Fisher Scientific is one of Norway´s leading biotechs and among the most profitable. The company has played a vital role in Norwegian biotech with the development of «Dynabeads», used all over the world to separate, isolate and manipulate biological materials.

Thermo Fisher’s Dynabeads are used in basic research, in billions of diagnostic tests, as well as in immunotherapy.

In May this year, Thermo Fisher Scientific was nominated for the “Norway’s smartest industrial company” award for the same technology. The smart element was using the beads in a completely new way on a microchip in combination with semiconductor technology. This link between biotech and electronics has created the instruments from Thermo Fisher which we now see in research institutes and diagnostic labs all over the world.

Ambitious research and development
– Thermo Fisher Scientific is carrying out an ambitious research and development effort in a very important area. The company is achieving this by using its own resources, seeking cooperation with exacting customers and drawing on public funding schemes from, among others, the Research Council of Norway. In this way, the company contributes to job creation as well as value creation, said Monica Mæland, Minister of Trade and Industry, according to The Research Council of Norway. She presented the Innovation Award during the Arendal Week in August.

The Research Council’s Innovation Award comprises a cash prize of NOK 500 000 and is given each year to a business or public entity that has demonstrated an outstanding ability to apply research results to create research-based innovation.

Funding Innovation in BioPharma and IT

What kind of work does it take to receive PERMIDES funding for innovative concepts and projects? Meet one of the companies that just received funding. 

 

22 collaboration projects will receive a total of 1,25 Million Euros from PERMIDES for innovation projects between small and medium sized enterprises (SMEs) from biopharma, bioinformatics and the IT sector. 

One of the lucky companies to receive innovation funding is Oslo Cancer Cluster member Myhere. For MyHere, it was especially important that the PERMIDES initiative is focused on the intersection between BioPharma and IT.

– Working with partners that are specialized in our field makes it easier to communicate the mission we are on, the concrete problems we are trying to solve and to qualify if we are a good match for each other or not. Furthermore, as we learned about the people and companies involved with PERMIDES, we discovered that we could learn a lot from the experiences of other SMEs in the program, says Jon-Bendik Thue, CEO at MyHere.

An innovative health app
MyHere’s mission is mainly carried out through the use of their app. This app, which pinpoints levels of Prostate Specific Antigen (PSA) in the bloodstream, enables a clearer outlook on potential prostate cancer and when to promptly, and timely, seek help. Thus, this app creates a balanced overview of prostate cancer that can save the patient and doctor from underdoing and overdoing the process. Essentially, the app is designed to save lives.

In this video, from MyHere’s webpage, the company explains the concept:

Essential health data
The funding will enable MyHere to start with a project that manages content from owners of health data. Health data is a tremendous resource, but unfortunately also tremendously underutilized. One important factor is the issue with getting consent from the owner of health data for research purposes. Typically, the owner is the individual the information was generated from, often in the role as a patient.

– As a provider of medical services directly to consumers, while at the same time organizing data across patient journeys, we are in a unique position to help solve the issue with consent for use of data. The funding from PERMIDES will allow us to build a dynamic data owner content management system, that will be integrated into our medical service platform. We are very excited about this project and we look forward to implementing it with our partner FramX, says Thue.

– Without this funding, we would have had to postpone the initiative without knowing when we would be able to realize it. Now we are thrilled that we will be able to hit the ground running right after the short Norwegian summer, he adds.

More winners in this round
Another Oslo Cancer Cluster member that got funding in this PERMIDES call is Arctic Pharma, a small start-up company committed to developing innovative anti-cancer drugs by exploiting the peculiar metabolic features of cancer cells.

These two Oslo Cancer Cluster members were among six Norwegian companies involved in four successful applications for Innovation Voucher funding. All of them will be able to initiate their joint projects in August and expect to see results early next year.

 

Doing More in Prognosis and Diagnosis

The project DoMore! aims to achieve better and faster diagnosis and prognosis with information and communication technology solutions. 

 

Technological innovation brightens the future ahead. With an increase in investment towards these areas, we create not only further potential in the technological field, but see betterment in the area it was produced for – such as productivity, reliability, effectiveness and so on. This is great news, especially in terms of cancer treatment where continuous betterment is essential. But how, and to what effect, is this done?

Project DoMore! has the answers.

The project, funded by the Norwegian Research Council and including members of Oslo Cancer Cluster’s team, debates the future of doing more with modernized thinking.

How do they do it?
This is done by putting more effort into research and development of information and communication technology solutions to supplement, or even replace, methods in pathology: the study of causality in diseases. DoMore!, in this case, will increase productivity and quality of cancer treatment.

Close-up of a cancerous tumour within the intestine. The green line represents manual marking of the tumour, while the blue is automated. Photo: Institute for Cancer Genetics and Informatics

The Ambition
The goal, then, is to decrease the slight human error brought on by complex decision making and visual observation to a computer basis with unbiased, reproducible and greater accuracy in algorithms. By doing this, DoMore! hopes to increase efficiency in pathology, methods and markers to aid the clinician in giving better and more personalised treatment to cancer patients everywhere.

On top of this, DoMore! believes the same efficiency will apply to patents, publications, products and spin-off companies, as well as decreasing overall cost and treatment time.

Harbinger of Innovation
In regards to the importance of this project, Ketil Widerberg, who is General Manager of Oslo Cancer Cluster, highlights:

– Project DoMore! furthers the innovative process. This combination of biology and technology will become increasingly important, especially in the area of pathology. Ultimately, Project DoMore! is setting a great example of being the harbinger of our adapting future.

Targeting the Big Three
As of now, project DoMore! will be focusing on three major cancer forms: lung, colorectal and prostate cancer. These account for 44% of all deaths brought on by cancer and are amongst the most common.

Better Prognosis and Diagnosis Ahead
Undoubtedly, project DoMore! is set out to achieve great things. Already within the bright future of 2021, they hope to offer much securer and faster systems for diagnosis and prognosis amongst cancer patients.

A Constant State of Liveliness

A driving force behind the collaboration between Ullern Upper Secondary School and Oslo Cancer Cluster is stepping down. This is her adventure.

After fifteen great and productive years at Ullern Upper Secondary School, Esther Eriksen steps down from her position as vice principle in the upcoming month. Esther, who has been responsible for many various tasks in her position, has been a part of Ullern’s transformative experience alongside Oslo Cancer Cluster’s emergence in 2009 and recounts her time at Ullern.

A flourish of innovation
Esther Eriksen describes the transformation and unification of Ullern Upper Secondary School and Oslo Cancer Cluster as being a progression from a strong belief in it’s potential to a flourish of innovation.

The collaboration has become a constant state of liveliness: from pupils attending classes, to research, to teamwork and a continuous process of growth.

Since 2009, the school and the cluster, with all its member companies and institutions, has unified to produce a collaborative arena for the pupils. This is an experience Eriksen describes nothing short of “wonderful, educational and groundbreaking”.

Diversity in teamwork
– The collaborative experience is incredible due to the pupils’ ability to take in experience in regards to teamwork. Not to mention they learn how knowledge from books can be translated to hands on work and ultimately get a feel for what life has in store for them, says Eriksen.

Esther Eriksen describes her own experience as being much of the same, and stresses the notion of working as a team.

– Diversity in teamwork is really important! We see this from well-received results and happy pupils, says Eriksen.

Future potential
In regards to the future of this collaboration, Vice Principle Eriksen expresses her desire to see the school continue down the path it has set out on. She wants to see the pupils continue to learn, gain opportunities and continue to work collaboratively.

– I wish the pupils would gain further awareness of the potential this unification brings, and hope to see increased interest in teamwork as an integrity.

The best of moments
Esther Eriksen also shares what she would consider the best moments of her time at Ullern, of which these were her favorite:

  1. When the new school first opened in the Oslo Cancer Cluster Innovation Park in 2015 – hard work finally turned to fruition
  2. Seeing how happy and motivated the pupils are when they do projects with scientists, businesses and hospitals in the cluster
  3. The emergence of vocational studies, such as electronics and health care studies, at Ullern Upper Secondary School

To conclude, Vice Principle Eriksen would like to leave the school and her colleagues this message: that she will continue to observe and follow the thriving development taking place at Ullern Upper Secondary School.

– This is only the beginning!